^(18)F-FDG-PET/CT显像对可疑乳腺癌复发的诊断与治疗价值

The value of FDG-PET/CT for diagnosis and trentment in suspicious recurrence of breast cancer

目的:评估18F-FDG-PET/CT显像对可疑乳腺癌复发的诊断与治疗意义。方法:回顾性评估46名有乳腺癌病史且在首次确诊后存在肿瘤标志物增高的患者所做的47份18F-FDG-PET/CT显像结果。结果:30名(65%)患者证实肿瘤复发,16名(35%)患者没有显示肿瘤复发的证据。31名患者得到32份不正常的PET/CT显像结果,15名患者的PET/CT结果正常。灵敏度、特异性、准确度分别为90%、71%、83%。PET/CT结果影响了24(52%)名患者的治疗方案。结论:对伴随肿瘤标志物升高的乳腺癌患者,相对于CT对肿瘤复发的诊断来说,PET/CT显像具有更大的优势,导致大部分患者治疗措施改变。

Objiective：To evaluate the value of 18↑F-FDG-PET/CT for diagnosis and trentment in suspicious recurrence of breast cancer.Methods：Forty-seven consecutive FDG-PET/CT studies of 46 women with a history of breast cancer presented with elevated serum tumor markers after their initial diagnosis were retrospectively evaluated.Results：Thirty（65%） patients had tumor recurrence,and 16（35%） showed no further evidence of disease.Thirty-one patients had 32 abnormal PET/CT studies,and 15 patients had normal with an overall sensitivity,specificity, and accuracy of 90%,71%,and 83%,respectively.PET/CT had an impact on the management of 24（52%） patients.Conclusion：In patients with breast cancer and rising tumor markers,FDG-PET/CT had high performance indices and was superior to CT for diagnosis of tumor recurrence,which led to changes mostly in the subsequent clinical management of these patients.