胃食管接合部癌组织中MIF的表达

The expression of macrophage migration inhibitory factor in carcinoma of gastro-esophageal junction tissue

目的:研究巨噬细胞移动抑制因子(MIF)在胃食管接合部癌组织中的表达及意义。方法:免疫组化检测40例胃食管接合部癌组织中MIF蛋白表达水平,分析与临床病理的相关性。结果:MIF蛋白在胃食管接合部癌组织中存在异常的高水平表达,与癌细胞的分化程度、肿瘤TNM分期密切相关。结论:MIF可能参与了胃食管接合部癌的发病机制,可以作为早期诊断、预测预后的潜在的指标之一。

Objective：To explore the expression of macrophage migration inhibitory factor（MIF） in carcinoma of gastro-esophageal junction.Methods：To examine the expression level of MIF in forty patients with carcinoma of gastro-esophageal junction by immunohistochemistry staining,and analyze the clinical pathology significance.Results：MIF was overexpressed in carcinoma of gastro-esophageal junction specimens,the expression of MIF closely correlated with tumor differentiation and the tumor TNM staging.Conclusion：MIF contributed to the pathogenesis of carcinoma of gastro-esophageal junction,and MIF can be conductd as one potential index to pretest the prognosis and early diagnosis of carcinoma of gastro-esophageal junction.