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BRAP rs3782886 A>G基因多态性与食管癌易感性的关系 被引量：1

Relationship of BRAP rs3782886 A>G polymorphism and susceptibility to esophageal cancer
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摘要 目的探讨中国汉族人群中乳腺癌易感基因相关蛋白(BRAP)rs3782886A>G基因多态性与食管癌发生风险的关系。方法采用基质辅助激光解吸电离飞行时间质谱(MALDI-TOFMS)技术分析380例食管癌(食管癌组)和380例非肿瘤组(对照组)BRAP rs3782886A>G基因多态性,计算各种基因型的食管癌发生风险。结果 Logistic回归分析显示,与携带BRAP rs3782886AA+AG基因型的群体相比较,携带BRAP rs3782886GG等位基因型群体的食管癌发病风险略有降低(OR=0.53,95%CI=0.26-1.09)。结论 BRAP rs3782886A>G基因多态性与食管癌的发病风险无明显相关。 Objective To investigate the relationship of BRAP rs3782886 A〉G polymorphism and susceptibility to esophageal cancer in Chinese Han population. Methods Genotypes were determined by matrix-assisted laser desorption/ionization time-of flight mass spectrometry（MAI.Dl TOF MS） method in 380 esophageal cancer cases（group E） and 380 controls without cancers（group C）. The risk factors for esophageal cancer were calculated. Results I.ogistic regression analysis revealed that the risk factor for developing esophageal cancer was slightly decreased in the people carrying BRAP rs3782886 C,G genotype compared to those carrying BRAP rs3782886 A〉G variam genotype（OR=0.53,95% CI=0. 26-1. 09）. Conclusion BRAP rs3782886 A〉G polymorphism has no significant association with susceptibility to esophageal cancer.
作者 李星 吴晓阳 仲宁 顾海勇 陈锁成
机构地区 江苏大学附属昆山人民医院胸外科 江苏大学附属镇江人民医院胸外科
出处 《江苏医药》 CAS CSCD 北大核心 2012年第21期2554-2556,共3页 Jiangsu Medical Journal
关键词 乳腺癌易感基因相关蛋白 食管癌 单核苷酸多态性 BRCAl-associated protein Esophageal cancer Single nucleotide polymorphism
分类号 R735 [医药卫生—肿瘤]
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参考文献7

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同被引文献29

  • 1顾东风,Reynolds K,杨文杰,陈恕凤,吴锡桂,段秀芳,蒲晓东,徐丽华,吴先萍,陈祥福,魏仁敏,陈娜萦,吴天一,王礼桂,姚才良,牟建军,马义峰,王晓飞,Whelton P,何江.中国成年人代谢综合征的患病率[J].中华糖尿病杂志（1006-6187）,2005,13(3):181-186. 被引量：580
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  • 3JAKUBOWSKA A,GRONWALD J,MENKISZAK J,et al.Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism[J].BMC Cancer,2008,8:90.
  • 4SKASKO E,KLUSKA A,NIWINSKA A,et al.Age at onset of bilateral breast cancer,the presence of hereditary BRCA1,BRCA2,CHEK2 gene mutations and positive family history of cancer[J].Onkologie,2009,32 (4):182-188.
  • 5CUI R,KAMATANI Y,TAKAHASHI A,et al.Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk[J].Gastroenterology,2009,137 (5):1768-1775.
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  • 7TANG J,XI S,WANG G,et al.Prognostic significance of BRCA1-associated protein 1 in colorectal cancer[J].Med Oneol,2013,30 (2):541.
  • 8ROMANOWICZ-MAKOWSKA H,SMOLARZ B,LANGNER E,et al.Analysis of microsatellite instability and BRCA1 mutations in patients from hereditary nonpolyposis colorectal cancer (HNPCC)family[J].Pol J Pathol,2005,56 (1):21-26.
  • 9OZAKIK,SATO H,INOUE K,et al.SNPs in BRAP associated with risk of myocardial infarction in Asian populations[J].Nat Genet,2009,41 (3):329-333.
  • 10HINOHARA K,OHTANI H,NAKAJIMA T,et al.Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease[J].J Hum Genet,2009,54 (11):642-646.

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江苏医药
2012年 第21期

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