慢性心力衰竭患者血清MMP-9和hs-CRP的表达

Expressions of serum MMP-9 and hs-CRP in patients with chronic heart failure

目的探讨基质金属蛋白酶9(MMP-9)和高敏C反应蛋白(hs-CRP)在慢性心力衰竭(CHF)患者的表达。方法 CHF患者120例,ELISA检测血清MMP-9表达,乳胶增强免疫比浊法检测血清hs-CRP水平。比较不同NYHA心功能状态患者MMP-9和hs-CRP的表达差异。结果随着心功能的恶化,MMP-9和hs-CRP的表达水平显著升高(P<0.05)。CHF患者外周血MMP-9和hs-CRP的表达水平呈正相关(r=0.716,P<0.01)。结论 CHF患者外周血MMP-9和hs-CRP表达水平随着心功能的减低而升高,MMP-9和hs-CRP表达可能参与了CHF心肌重构的病理过程。

Objective To investigate the changes of serum matrix metalloproteinase-9（MMP-9） and high sensitive C-reactive protein（hs-CRP） expressions in the patients with chronic heart failure （CHF）. Methods A total of 120 CHF patients was divided into 4 groups according to NYHA cardiac function classes of Ⅰ , Ⅱ, Ⅲand Ⅳ. The expression levels of MMP-9 and hs-CRP were detected with ELISA and I.atex enhanced immunoturhidimetric assay, respectively, and compared among 4 NYHA cardiac cardiac function classes. Results The expression levels of MMP-9 and hs-CRP were increased as the cardiac function became worsen（P〈0. 05）. The expression of serum MMP-9 was positively correlated to that of hs-CRP（r=0. 716,P〈0. 01）. Conclusion When the cardiac dysfunction becomes severe in CHF patients,the expressions of MMP-9 and hs-CRP are remarkably increased, which may participate in the myocardial remodeling of CHF.