期刊文献+

人上皮生长因子受体2在胃癌发生发展中的表达及临床意义 被引量:2

原文传递
导出
摘要 人上皮生长因子受体2(human epidermal growthfactor receptor 2,HER2)为一促癌基因,其扩增与肿瘤侵袭、转移,化学治疗耐药及预后不良有关。HER2蛋白过表达或基因扩增的患者使用抗HER2重组单克隆抗体曲妥单抗(transtuzumab)可提高生存率。
出处 《中华消化杂志》 CAS CSCD 北大核心 2012年第10期703-706,共4页 Chinese Journal of Digestion
  • 相关文献

参考文献9

  • 1Moelans CB, van Diest PJ, Milne AN, et al. Her-2/neu testing and therapy in gastroesophageal adenocarcinoma. Patholog Res Int, 2010,2011:674182.
  • 2Bang YJ, Van Cutsem E, Feyereislova A,et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (TOGA): a phase 3, open-label, randomized controlled trial. Lancet, 2010,376 : 687-697.
  • 3Ruschoff J, Dietel M, Baretton G, et al. HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing. Virchows Arch, 2010,457:299-307.
  • 4Hofmann M, Stoss O, Shi D, et al. Assessment of a HER2 scoring system for gastric cancer: results from a validationstudy. Histopathology, 2008,52 : 797-805.
  • 5Kuesters S, Maurer M, Burger AM, et al. Correlation of ErbB2 gene status, mRNA and protein expression in a panel of>100 human tumor xenografts of different origin. Onkologie, 2006,29 : 249-256.
  • 6Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer, 2002,2 : 161-174.
  • 7Kim S, Han J, Lee SK, et al. Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer ceils. Cancer Lett, 2012,314: 147- 154.
  • 8Pellikainen JM, Ropponen KM, Kataja VV, et al. Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis. Clin Cancer Res, 2004,10: 7621-7628.
  • 9Dowdy SC, Mariani A, Janknecht R. HER2/Neu-and TAK1- mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. J Biol Chem, 2003,278. 44377-44384.

同被引文献17

引证文献2

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部