远隔肢体缺血适应对人体中心动脉压的影响

Effect of remote limb ischemic conditioning on human central aortic pressure

目的探讨通过重复肢体缺血再灌注进行远隔缺血适应对中心动脉压的影响。方法随机选取健康自愿者,给予单侧肢体5次缺血/再灌注进行缺血适应,选取实验前、每次肢体缺血中、再灌中及操作结束后30 min共12个时间点测量中心动脉舒张压、收缩压、增强压及增压指数。结果每个时间点上,重复肢体缺血再灌注对中心动脉舒张压、收缩压有降低的趋势,对增强压及增压指数无明显影响。结论通过重复肢体缺血再灌注进行远隔肢体缺血适应对中心动脉压无不利影响,是一种安全易行的治疗措施。

Objective To investigate the effect of remote limb ischemic conditioning（RLIC） by repeating limb ischemia-reperfusion on central aortic pressure. Methods Healthy volunteers were randomly selected and performed RLIC （intermittent arm ischaemia through five cycles of 5 min inflation and 5 rain deflation of a blood-pressure cuff）. Central aortic diastolic pressure, systolic pressure, augmentation pressure and augmentation index were measured at various time point （before RLIC, during ischemia, during reperfusion and 30 minutes after the operation）. Results Repetitive limb ischemia reduced central aortic diastolic pressure and systolic pressure, but the augmentation pressure and augmentation index at each time point were not affected. Conclusions RLIC by repeating limb ischemia-reperfusion is not detrimental to central aortic pressure and is a safe and easy treatment measure.