不同艾灸时程对高脂血症调脂效应影响的研究

Study on the impacts of different time of moxibustion on regulating lipid effects of hyperlipidemia

目的:观察不同艾灸时程对高脂血症患者血脂及安全性的影响。方法:将76例高脂血症患者随机分为10分钟艾灸组(25例),20分钟艾灸组(25例)和30分钟艾灸组(26例),每组所选穴位相同,均为神阙、足三里、丰隆、三阴交,3组分别施灸10min、20min、30min,每周3次,12次为一疗程,共治疗2个疗程。观察治疗前后血脂各项指标、空腹血糖的变化,并对其肝、肾功能安全性指标进行初步评价。结果:艾灸治疗后患者总胆固醇、甘油三酯、低密度脂蛋白胆固醇、空腹血糖均明显降低(均P<0.001),高密度脂蛋白变化不显著(P>0.05)。30分钟艾灸组较10分钟艾灸组在调节总胆固醇和低密度脂蛋白胆固醇方面作用更显著(P<0.01,P<0.05),与20分钟艾灸组比较差异无统计学意义(P>0.05)。艾灸治疗后患者尿素氮下降明显(P<0.05),其余安全性指标差异无统计学意义(均P>0.05)。结论:艾灸可有效、安全地降低高脂血症患者血脂水平,不同艾灸时程干预后血脂的下降程度略有不同,30分钟艾灸组的下降程度明显优于10分钟艾灸组。

Objective To observe the impacts of different time of moxibustion on its regulating lipid effects and safety of hyperlipidemia.Methods Seventy-six cases of hyperlipidemia patients were randomly divided into three groups： including moxibustion 10 min group（group A,25 cases）,moxibustion 20 min group（group B,25 cases） and moxibustion 30 min group（group C,26 cases）.All of these three groups choose the same acupoints,Shenque（CV 8）,Zusanli（ST 36）,Fenglong（ST 40） and Sanyinjiao（SP 6） were selected.These three groups were treated with moxibustion for 10 min,20 min and 30 min,respectively,three times a week,12 times constituted one course,two courses were required for each group.All indices of blood lipid and fasting blood glucose were observed before and after treatment,and the preliminary evaluation was made on the safety of hepatic and renal function.Results There were significant decrease in total cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol（LDL-C）,and blood sugar after moxibustion treatment（all P0.001）,there was no significant difference of high density lipoprotein cholesterol（HDL-C） before and after treatment（P0.05）.The group C played more prominent role than group A in regulating the TC（P0.01） and LDL-C（P0.05）,there was no significant difference between group C and group B（P0.05）.The blood urea nitrogen（BUN） was significantly reduced after moxibustion treatment（P0.05）,and there were no significant differences of other safety indices before and after treatment（all P0.05）.Conclusion Moxibustion can effectively and safely reduce the blood lipid level of hyperlipidemia patients,the decreasing degree of lipid is different with different time of moxibustion after treatment,and the decreasing degree in moxibustion 30 min group is significantly better than that in moxibustion 10 min group.