TREK1钾通道与抑郁症

TREK1 potassium channels and depression

抑郁症日益成为全球性社会问题,但是其致病机制目前尚不明确。最近研究表明,双孔钾通道TREK1可能是新的抗抑郁药物的作用靶点。本文综述了双孔钾通道的结构与功能研究进展以及该通道与抑郁症的关系,着重阐述了TREK1钾通道在抗抑郁、神经保护和神经重塑等过程中的重要作用,并说明了TREK1钾通道与单胺类递质及其受体的相互作用的分子机制。本文还讨论了今后与抑郁症相关的重要的研究方向。

Major depression disorder is an increasing heavy burden in modern society, but its pathological mechanism is still vague. Recent evidence indicated that two pore potassium channel, TREK1, is one of the important drug targets of antidepressants. The structural and functional research progress of TREK1 potassium channel were reviewed with an emphasis on its roles in anti-depression, neuronal protection, and neuronal plasticity. The complicated interactions between TREK1 potassium channel and monoamine transmitters- receptors were also reviewed and future directions to explore the underline mechanism were also discussed.