基于天然产物的药物研发对创新中药研究的启示——TTD收录天然药物分析

Inspirations from natural products based drug research and development for Chinese medicine research —Analysis of natural products recoded in TTD

天然产物一直是新药研发的重要源泉,创新中药研发是中药现代化、国际化的关键环节。但由于中药系统的复杂性,目前创新中药研发尚存在诸多困难和困惑。基于靶点的药物研发是药物发现的主要模式和手段。TTD(therapeutic target database)是新加坡国立大学开发的治疗靶点数据库,除收录大量的药物靶点信息外,还包含了大量天然产物的相关信息。本文简单介绍了TTD,通过分析TTD中收录的天然来源的药物/化合物,探讨了对创新中药研发的启示。

Natural product is an important source of new drug research and development （R＆D）. Traditional Chinese medicine （TCM） innovation is the key step for its modernization and internationalization. However, due to the complexity of TCM, there are many difficulties and confusions in this process. Target-based drug discovery is the mainstream model and method of R＆D. TTD, short for therapeutic target database, is developed by National University of Singapore. Besides a large amount of information on drug targets, the database also contains considerable information related to natural products. This paper briefly introduces the TTD, analyzes the natural products derived drngs/compounds recorded in TTD, which we think might provide some inspiration for the innovation of TCM.