预测体外受精中卵巢反应性相关因素分析

Analysis of Correlation Factor for the Prediction of Ovarian Response in IVF Cycles

目的:比较基础抑制素B(basal inhibin B,bINHB)、基础卵泡刺激素(bFSH)、年龄、窦卵泡计数(AFC)对于体外受精中卵巢反应的预测价值。方法:选取首次施行体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)患者796例,于促排卵开始前1个月,测定月经第3日血清bINHB、bFSH水平,B超测定当日卵巢内AFC,分别比较其与获卵数的相关性。结果:bINHB、AFC与获卵数呈正相关性,相关系数(r)分别为0.147和0.661;bFSH、年龄与获卵数呈负相关,r分别为-0.239和-0.355,均P<0.001。按|r|值行相关性排序,bINHB、bFSH、年龄、AFC与获卵数相关性递增。结论:bINHB、bFSH、年龄、AFC均可以预测卵巢反应性,AFC是预测卵巢反应最好的指标。

Objective： To compare the basal inhibin B （blNHB） level, the basal level ofFSH （bFSH）, age and antral follicle count （AFC） for the prediction of ovarian response to controlled ovarian hyperstimulation （COH） during assisted reproduction treatment. Methods： Serum blNHB level, bFSH level and AFC on day 3 of menstrual cycle were detected before ovarian stimulation in 796 patients undergoing their first cycle of IVF/ICSI-ET. Corre- lation between the number of oocytes obtained and blNHB, bFSH, age, AFC were compared. Results： The blNHB and AFC positively correlated with ooeytes number （r= 0.147, 0.661, respectively, P〈0.001）. The bFSH level and age showed negative correlation with oocytes number （r=-0.239, -0.335, respectively, P〈0.001）. According to absolute value of correlation coefficient with number of retrieved eggs, AFC was the best predictor of ovarian response, followed by age, bFSH and blNHB. Conclusion： Basal levels of INHB and FSH, age and AFC all could predict ovarian response, but AFC was the best predictive factor.