沙丁胺醇与布地奈德联合雾化吸入治疗小儿哮喘临床疗效及安全性研究

Study on the clinical efficacy and safety of aerosol inhalation of salbutamol combined with budesonide for treatment of pediatric asthma

目的:探讨沙丁胺醇与布地奈德联合雾化吸入治疗小儿支气管哮喘的临床疗效及安全性。方法:回顾性分析2011年1月～2012年1月在该院接受治疗的82例支气管哮喘患儿的临床资料,观察沙丁胺醇与布地奈德(观察组)联合雾化吸入与单一沙丁胺醇(对照组)雾化吸入治疗的临床疗效及不良反应情况,并进行对比分析。结果:观察组总有效率为95.12%,明显高于对照组的78.05%(P<0.05);观察组患儿症状消退时间及平均住院时间均明显低于对照组(P<0.01);观察组肺功能改善明显优于对照组(P<0.05);两组不良反应均较轻微。结论:沙丁胺醇与布地奈德联合雾化吸入法治疗小儿支气管哮喘具有疗效好、见效快、症状改善明显、不良反应少等诸多优点,可作为目前治疗小儿支气管哮喘的一种较佳治疗方案。

Objective： To explore the clinical efficacy and safety of aerosol inhalation of salbutamol combined with budesonide for treatment of pediatric asthma. Methods ： The clinical data of 82 infants with bronchial asthma who were treated in the hospital from January 2011 to January 2012 were analyzed retrospectively; the clinical efficacies and adverse reactions in observation group （aerosol inhalation of salbutamol combined with budesonide ） and control group （aerosol inhalation of salbutamol ） were observed, compared, and analyzed. Results： The total effective rate in observation group was 95.12%, which was statistically significantly higher than that in control group （78.05%） （P 〈 0. 05 ） ; The disappearance time of symptoms and mean hospitalization time in observation group were statistically significantly lower than those in control group （P 〈 0. 01 ） ; the improvement of pulmonary function in observation group was better than that in control group （ P 〈 0. 05 ） ; the adverse reactions in the two groups were mild. Conclusion： Aerosol inhalation of salbutamol combined with budesonide has the advantages of good curative effect, fast effect, obvious improvement of symptoms, and less adverse reactions, which can be used as a good therapeutic schedule for treatment of pediatric asthma currently.