先天性梅毒患儿生长发育与神经心理发育随访研究

Follow-up study on growth and development and neuropsychological development of infants with congenital syphilis

目的:探讨经正规驱梅治疗后的先天性梅毒儿生长发育和神经心理发育与正常儿是否存在差异及孕母正规治疗后的先天性梅毒儿与孕母未经正规治疗的先天性梅毒儿之间生长发育和神经心理发育是否存在差异。方法;孕母经过正规驱梅治疗的先天性梅毒患儿25例及孕母未经过正规驱梅治疗的先天性梅毒患儿25例作为试验组,同期在医院儿童保健科体检随访的健康婴儿25例作为对照组,进行系统追踪随访,分别在儿童3、6、9、12、18及24个月时进行生长发育(身高、体重、头围)及神经心理发育(0～6岁小儿神经心理发育诊断量表)评估。结果:先天性梅毒患儿身高增长及神经心理发育均低于正常儿,差异有统计学意义(P<0.05);孕母未经过正规驱梅治疗的先天性梅毒患儿身高低于孕母经过正规驱梅治疗的先天性梅毒患儿,差异有统计学意义(P<0.05)。结论:经正规治疗后的先天性梅毒影响儿童生长发育及神经心理发育。

Objective： To explore whether there were differences in growth and development, and neuropsychological development between children who accepted the regular treatment of congenital syphilis and healthy children, as well as between congenital syphilis children whose mothers received regular treatment of syphilis during pregnancy and those who didnt. Methods： A total of 25 children with congenital syphilis whose mothers received regular treatment of syphilis during pregnancy and 25 children with congenital syphilis whose mothers didnt receive regular treatment of syphilis during pregnancy were selected as experimental group, 25 healthy children who received physical examination in the hospital during the same period were selected as control group; all the children were tracked and followed up systematically, evaluation of growth and development （ body height, body weight, and head circumstance） , and neuropsychological development （ with 0 - 6 - year - old infant neuropsychological development diagnosis scale） was conducted at 3, 6, 9, 12, 18, and 24 months. Results ： The increase of body height and neuropsychologieal development of children with congenital syphilis were statistically lower than those of healthy children （ P 〈 0. 05 ） ; body height of children with congenital syphilis whose mothers didnt receive regular treatment of syphilis during pregnancy was shorter than that of children with congenital syphilis whose mothers received regular treatment of syphilis during pregnancy （ P 〈 0. 05 ） . Conclusion ： Congenital syphilis after regular treatment affects growth and development, and neuropsychological development of children.