摘要
在反相乳液体系中合成β-CD微球载体,使其对甲芬那酸进行包合;通过L9(34)正交实验对包合条件进行优化,并采用电镜扫描、红外、X射线衍射和热重对微球及包合物进行了表征,结果表明最佳包合条件为β-CD微球1g,甲芬那酸的浓度0.003g/mL,反应时间3h,反应温度70℃。通过紫外分光光度法测定最佳包合条件下的载药量为1.90%,包封率为79.2%,影响因素的主次顺序为载药温度>β-CD微球的量>甲芬那酸的浓度>载药时间。
The β-cyclodextrin microspheres were synthesized in inverse emulsion , then its adsorption to mefenamic acid were studied . The preparation process was optimized through the L^9 (3^4) orthogonal experimental design and the structure and performance were characterized by scanning electron microscope, FT-IR spectroscopy, X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The results showed that the most optimized conditions were as following, m (β-CD microsphere/g) lg, mefenamic acid concentration 0. 003g/mL, time 3h, temperature 70℃ Drug loadings and sealed rate were 1.90% and 79.2% ,respectively at the most optimized conditions by means of ultraviolet spectrophotometry. The sequence of influence factors was the reaction temperature 〉 the quantity of β-cyelodextrin microsphere 〉 the concentration of mefenamic acid 〉 the reac tion time.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2012年第21期2973-2976,2980,共5页
Journal of Functional Materials
基金
国家自然科学基金资助项目(50573046)
陕西科技大学研究生创新基金资助项目(SUST-B)
关键词
甲芬那酸
β-环糊精微球
载药量
包封率
正交实验
mefenamic acid
β-cyclodextrin microsphere
drug loadings
sealed rate
orthogonal design