摘要
目的分析脑梗死患者脑白质疏松(leukoaraiosis,LA)与24 h尿微量白蛋白排泄率(urine microalbumin excretion,UAER)的相关性。方法选择2011年6～12月住南京军区南京总医院所有首次急性脑梗死患者120例,根据是否合并LA分为LA组45例,无LA组75例,详细记录患者一般临床资料,检测24 h UAER及空腹血糖、血脂等生化指标。比较2组一般临床危险因素及24 h UAER,并进行多因素回归分析。结果 120例脑梗死患者中,合并LA 45例,占37.5%。与无LA组比较,LA组患者年龄、高血压发生率、24 h UAER水平明显升高,差异有统计学意义(P<0.05,P<0.01);LA与24 h UAER水平呈正相关(r=0.681,P<0.01);24 h UAER(OR=1.100,95%CI:1.03～1.17,P=0.002)是LA的独立危险因素。结论 LA与24 h UAER密切相关,24 h UAER可以作为小血管病损伤的一个标记物,对LA的诊断和治疗有重要意义。
Objective To study the correlation between leukoaraiosis （LA） and 24 h urine microalbumin excretion （UAER）in patients with cerebral infarction. Methods One hundred and twenty patients with first acute cerebral infarction admitted to our hospital from June 2011 to December 2011 were included in this study. Their general clinical data were recorded, and their 24 h UAER and serum fasting blood glucose, blood-lipid and fibrinogen levels were measured. Differ- ence in general clinical risk factors and UAER was compared between cerebral infarction patients with or without IrA. General clinical risk factors and UAER were analyzed by multivariate regres- sion analysis. Results Of the 120 cerebral infarction patients,45（37. 5〈） were complicated by LA. The age,the incidence of hypertension and the 24 h UAER were significantly higher in pa- tients with simple cerebral infarction than in those with LA（P〈0.05, P〈0.01）. Binary logistic regression analysis showed that the 24 h UAER was correlated with LA even after adjustment of risk factors such as age and sex（OR= 1. 100,95〈CI〈1.03--1.17 ,P=O. 002）. The severer the LA was,the higher the UAER was（r=0. 681,P〈0. 01）. Conclusion Age,hypertension and 24 h UAER are correlated with LA in cerebral infarction patients. The severity of LA is positively related with 24 h UAER which can thus be used a marker for small blood vessel lesion and is of great significance in diagnosis and treatment of IrA.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2012年第11期1138-1140,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
