摘要
合理应用抗生素是围手术期处理的重要内容之一。某些抗生素的应用会对部分病人的凝血功能产生影响,尤其在肝肾功能不全、术前长时间禁食、营养状况不良及癌症等病人中较易发生,主要是由体内维生素K合成不足所致;抗生素还可与华法林等抗凝药物相互作用而易导致出血。因此,临床医生在围手术期应用抗生素时要严格掌握药物的适应证,评估病人的基本状况,密切关注各项凝血指标的变化,在出现出血或凝血指标异常的情况下,需考虑到有无药物之间的相互作用,合理补充维生素K或各种凝血因子。
Perioperative use of antibiotics is one of many important components of perioperative disposal. Certain antibiotics have influences on the coagulation function of some patients. The influence is mainly caused by the deficiency in vitamin K synthesis. Patients with hepatic failure, renal failure, malnutrition and cancer are more vulnerable. Furthermore, antibiotics can interact with anticoagulants such as warfarin and lead to bleeding events. So when using antibiotics during the perioperative period, clinicians should grasp the drug indications, evaluate the basic conditions of patients, notice the interactions of drugs, and pay close attention to the change of coagulation indicators.
出处
《中国实用外科杂志》
CSCD
北大核心
2012年第11期889-891,共3页
Chinese Journal of Practical Surgery
关键词
围手术期
抗生素
凝血功能
perioperative period
antibiotics
coagulation function
