严重脓毒症致凝血功能障碍的新认识

New opinion of coagulation disorders resulted from severe sepsis

脓毒症常合并不同程度的凝血功能障碍。组织因子介导的促凝机制增强,生理抗凝机制下调以及纤溶系统功能抑制是脓毒症凝血功能障碍发生的主要机制。针对凝血系统功能障碍的不同机制给予针对性的药物治疗,对改善脓毒症病人的预后可能有益。

Sepsis is almost invariably associated with coagulation disorders. The mechanisms underlying septic coagulopathy including tissue factor induced enhancement of procoagulation, down-regulation of physical anticoagulation pathway and inhibition of fibrinolysis. Appropriate pharmacotherapy aiming directly at different mechanisms of septic coagulopathy may be effective for severe sepsis patients.