摘要
MMP11属于MMPs家族,它与肿瘤的浸润转移密切相关.探讨MMP11在肺鳞癌和腺癌组织中的表达,及其与浸润转移和预后的关系.应用免疫组化检测50例肺鳞癌和38例肺腺癌组织中MMP11蛋白的表达.结果显示,MMP11在肺鳞癌和腺癌组织中的阳性率分别为68.0%(34/50)和73.7%(28/38)(P=0.563).MMP11的阳性率随着肺癌T分期的增加、淋巴结转移和TNM分期的增加而增加(P<0.05).Kaplan-meier单因素生存分析显示,MMP11表达(P=0.001)、T分期(P=0.009)、淋巴结转移(P<0.001)和TNM分期(P<0.001)对生存期的影响有统计学意义.Cox多因素分析显示,只有TNM分期(P=0.028)是肺癌的独立预后危险因素,MMP11(P=0.105)不是肺癌的独立预后危险因素.MMP11的表达与肺癌的浸润、转移及生存期密切相关.
Matrix metalloproteinase 11(MMP11),a member of the matrix metalloproteinase family,was con-sidered to be associated with the tumor cell invasion and metastasis.The expression of MMP11,and its rela-tionship with invasion,metastasis and prognosis of lung squamous carcinoma and adenocarcinoma were ana-lyzed.The expression of MMP11 was detected by immunohistochemistry in 50 specimens of lung squamous carcinoma and 38 specimens of lung adenocarcinoma tissues.Results indicated that the expression rate of MMP11 in lung squamous carcinoma and adenocarcinoma were 68.0%(34/50) and 73.7%(28/38)(P=0.563),respectively.The expression rate of MMP11 was increased in advanced T stages,lymphatic metastasis and advanced TNM stages of lung cancer(P0.05).MMP11 positive expression(P=0.001),advanced T stages(P=0.009),lymphatic metastasis(P0.001) and advanced TNM stages(P0.001) were negative prognostic factors,which were showed by Kaplan-meier univariate analysis.TNM stages(P=0.028) was only an independent prognostic factor,but MMP11(P=0.105) was not an independent prognostic factor of lung cancer,which were showed by Cox model analysis.The results indicated that the invasion,metastasis and poorer prognosis were correlate closely with over-expression of MMP11 in lung cancer.
出处
《生命科学研究》
CAS
CSCD
北大核心
2012年第5期423-427,共5页
Life Science Research
关键词
肺癌
MMP11
浸润和转移
预后
lung cancer
MMP11
invasion and metastasis
prognosis