左甲状腺素钠治疗老年甲状腺功能减退综合征疗效观察及安全性研究

目的探讨左甲状腺素钠治疗老年甲状腺功能减退症的疗效及安全性。方法选取2009年3月～2010年11月湖南省洪江市人民医院治疗的甲状腺功能减退老年患者64例,随机分为两组,各32例。对照组采用甲状腺片治疗,治疗组采用左甲状腺素钠治疗。对比分析两组患者治疗前后的TSH、FT4及FT3差异及不良反应情况。结果两组患者的TSH、FT4及FT3水平均较治疗前明显改善,但治疗组TSH恢复所用时间较短,且治疗组不良反应发生率较对照组低,差异有统计学意义(P<0.05)。结论左甲状腺素钠治疗老年甲状腺功能减退症十分有效,且效价稳定,不良反应少,是一种安全有效的治疗甲状腺功能减退症药物。

Objective To investigate the clinical efficacy and safety of levothyroxine sodium in the treatment of elderly hypothyroidism. Methods 64 hypothyroidismL elderly patients were chosen in our hospital from March 2009 to November 2010, they were randomLy divided into control and treatment group, 32 cases in each group, control group patients with the treatment of thyroid tablets, treatment group patients with levothyroxine sodium therapy, comparative analysis of two groups patients＇ TSH, FT4 and FT3 difference before and after treatment, and adverse reactions.Results The two groups patients＇ TSH, FT4 and FT3 levels improved significantly after treatment and the TSH recovery time of treatment group is shorter and with less adverse reactions compared with the control group （P〈0.05）. Conclusion Levothyroxine sodium in the treatment of elderly hypothyroidism is very effective, stable titer less adverse reactions,it is a safe effective treatment of hypothyroidism drugs.