1Coleman R E. Metastatic bone disease:clinical features, pathophysiology and treatment strategies [ J]. Cancer treatment reviews, 2001,27 (3) :165-176.
2Mundy G R. Metastasis to bone:causes, consequences and therapeutic opportunities [ J ]. Nature Reviews Cancer,2002,2 ( 8 ) :584-593.
3Siegel P M J. Massague, Cytostatic and apoptotic actions of TGF - [ beta] in homeostasis and cancer[ J]. Nature Reviews Cancer,2003, 3( 11 ) :807-820.
4Kwok S, Rittling S R, Partridge N C, et al. Transforming growth factor - betal regulation of ATF - 3 and identification of ATF - 3 target genes in breast cancer cells [ J ]. J Cell B iochem,2009,108 (2) :408- 414.
5Alexaki V I, Javelaud D, Van Kempen L C, et al. GLI2 - Mediated Melanoma Invasion and Metastasis[J]. Journal of the National Cancer Institute,2010,102 ( 15 ) : 1148-1159.
6Johnson R W, Nguyen M P, Padalecki S S, et al. TGF - 13 promotion of Gli2 - induced expression of parathyroid hormone - related protein, an important osteolytic factor in bone metastasis, is independent of canonical hedgehog signaling[ J]. Cancer Research ,2011,71 ( 3 ) : 822 -831.
7Mohammad K S, Javelaud D, Fournier P G, et al. TGF - 13 - RI kinase inhibitor SD - 208 reduces the development and progression of melanoma bone metastases [ J ]. Cancer Research, 2011,71 ( 1 ) : 175- 184.
8Choi Y J,Kim S T,Park K H,et al. The serum bone morphogenetic protein -2 level in non -small -cell lung cancer patients[ J]. Medical Oncology,2012,29 ( 2 ) :582-586.
9Lorch G, Gilmore J L, Koltz P F, et al. Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous -cell carcinoma in athymic mice [ J ]. British Journal of Cancer,2007,97 ( 2 ) : 183-193.
10Vaupel P. The Role of hypoxia - induced factors in tumor progression [ J ]. The Oncologist,2004,9 ( suppl 5 ) : 10-17.
3Wong MC, Wu CH, Wang HH, et al. Association betweenthe 8-item Morisky medication adherence scale (MMAS-8)score and glycaemic control among Chinese diabetes pa-tients [j]. J Clin Pharmacol, 2015,55(3): 279-287.
4Hjermstad MJ,Fayers PM, Haugen DF, et al. Studies com-paring Numerical Rating Scales, Verbal Rating Scales, andVisual Analogue Scales for assessment of pain intensity inadults: a systematic literature review [J]. J Pain SymptomManage, 2011,41(6): 1073-1093.
