摘要
目的探讨丹红注射液对急性心肌梗死(AMI)溶栓患者近期和远期心肌的保护作用。方法将56例AMI溶栓患者随机分为2组。对照组26例给予常规溶栓治疗,治疗组30例在常规治疗的基础上给予丹红注射液静脉滴注。2组均2周为1个疗程,1个疗程后观察2组血管再通率、再灌注心律失常发生率[溶栓后2 h内出现心律失常(心室颤动、房室传导阻滞、窦性心动过缓及室性心动过速)]、严重心力衰竭发生率、住院期间死亡率、心肌酶[肌酸激酶(CK)及肌酸激酶同工酶(CK-MB)]峰值浓度及恢复正常时间,治疗后3个月查心脏彩超查看左室舒张末期内径(LVEDd)和左心室射血分数(LVEF),同时记录心肌梗死再发率和再住院率。结果 2组血管再通率、再灌注心律失常发生率、严重心力衰竭发生率、住院期间死亡率、CK峰值浓度、CK-MB峰值浓度及恢复正常时间比较差异均有统计学意义(P<0.05),治疗组疗效优于对照组。治疗3个月后,2组LVEDd、LVEF、心肌梗死再发率及再住院率比较差异均有统计学意义(P<0.05)。结论丹红注射液能明显提高AMI患者溶栓再通率,减少心力衰竭及心律失常的发生率,减少死亡率,对远期保护缺血心肌损伤及心功能的恢复有良好的作用。
Objective To investigate short and long term myocardial protection of Danhong injection on thrombolysis patients with acute myocardial infarction (AMI). Methods 56 cases of AMI patients treated with thrombolysis, were randomly divided into two groups, control group received conventional thrombolytic therapy, the treatment group on the basis of the conventional treatment given Danhong intravenous injection. Recanalization rate, cardiac reperfusion disorders, the incidence of severe heart failure, hospital mortality, myocardial enzyme peak con- centration and recovery time were compared after a course in two groups. Echocardiography view of left ventricular end - diastolic volume(LVEDV) and left ventricular ejection fraction(LVEF) , while record the incidence of myocar- dial infarction and re - re - hospitalization rates was check 3 months after treatment. Results There were statistical- ly significant differences between two groups on recanalization rate, the incidence of reperfusion arrhythmias, the inci- dence of severe heart failure, hospital mortality peak concentration of CK, CK - MB peak concentration and recovery time( P 〈0.05). After 3 months of treatment, there were significant differences between two groups on LVEDd, LVEF, myocardial infarction, recurrence rate and re -hospitalization rates ( P 〈 O. 05 ). Conclusion Danhong in- jection can significantly improve thrombolytic recanalization rate in patients with AMI to reduce the incidence of heart failure and arrhythmia, reduced mortality, ischemic myocardial damage on long - term protection and recovery of car- diac function have a good effect.
出处
《河北中医》
2012年第10期1528-1530,共3页
Hebei Journal of Traditional Chinese Medicine
关键词
心肌梗死
急性病
丹参
红花
注射剂
中医药疗法
Danhong injection
Myocardial infarction
Traditional Chinese medicine therapy