期刊文献+

胃癌HER2信号通路及曲妥珠单抗临床应用进展 被引量:3

Progress of HER2 Signaling Pathway in Gastric Cancer and the Clinical Application of Trastuzumab
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摘要 胃癌是全世界常见的消化系统恶性肿瘤之一,是我国第二大肿瘤,5年生存率不足20%。近年来,肿瘤的分子分型与分子靶向治疗方兴未艾,在肺癌、乳腺癌、大肠癌等肿瘤中已初见成效,用于临床治疗指导,疗效预测及预后判断。而胃癌的靶向治疗却迟迟未见端倪,
作者 付强 陈元
出处 《药品评价》 CAS 2012年第27期8-12,共5页 Drug Evaluation
关键词 胃癌 HER2 信号通路 曲妥珠单抗 Gastric cancer HER2 Signaling pathway Trastuzumab
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参考文献34

  • 1Hsu SC, Hung MC. Characterization of a novel tripartite nuclear localization sequence in the EGFR family [J]. J Biol Chem, 2007, 282(14): 10432-10440.
  • 2Milanezi F, Carvalho S, Schnfitt FC. EGFR/HER2 in breast cancer: a biological approach for molecular diagnosis and therapy [J]. Expe Rev Mol Diagu, 2008, 8(4): 417.
  • 3Niemiec JA, Adamczyk A, Maecki K, et al. Relationships between immunophenotype, Ki-67 index, microvascular density, Ep-CAM/ P-cadherin, and MMP-2 expression in early-stage invasive duetal breast cancer [J]. Appl [Epub ahead of print] Mol Morpho12012 Apr 23.
  • 4Erdem O, Dursun A, Cosktm U, et al. the prognostic value of p53 and cerbB-2 expression, proliferative activity and angiogenesis in nodeegative breast cancer [J]. Tumor, 2005, 91(1): 46-52.
  • 5Rivas MA, Tkach M, Beguelin W, et al. Transactivation of ErbB- 2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation [J]. Breast Cancer Res Treat, 2010, 122(1): 111-124.
  • 6Yu HG, Ai YW, Yu LL, et al. Phosphoinositide3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death [J]. Int J Cancer, 2007, 122(2): 433-443.
  • 7Brewer GJ. Copper lowering therapy with tetrathiomolybdate as anantiangiogenic strategy in cancer [J]. Curr Cancer Drug Targets, 2005, 5(3): 195-202.
  • 8Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2 positive advanced gastric or gastro- oesophageal junction cancer (TOGA): a phase 3, open-label, randomised controlled trial [J]. Lancet, 2010, 376(9742): 687-697.
  • 9邓勇军,李海滨,沈剑,杨鸿生,洪志鹏,李定彪.食管鳞癌中人表皮生长因子受体Her-2/neu蛋白的过表达及预后意义[J].中国现代医学杂志,2009,19(24):3726-3730. 被引量:10
  • 10Verri E, Guglielmini P, Puntoni M, et al. HER2/neu oncoprotein overexpression in epithelial ovarian cancer: evaluation of its prevalence and prognostic siiflcance [J]. Clin Study, 2005, 68(2-3): 154-16l.

二级参考文献20

  • 1徐建明,宋三泰.表皮生长因子受体酪氨酸激酶靶向药物与化疗联合应用的合理设计[J].中华肿瘤杂志,2004,26(6):321-323. 被引量:20
  • 2刘昭前,李慧华,周宏灏.吉非替尼治疗非小细胞肺癌的研究进展[J].中国现代医学杂志,2005,15(20):3133-3136. 被引量:5
  • 3Emens LA. Trastuzumab: targeted therapy for the management of HER-2/neu-overexpressing metastatic breast cancer [J]. Am J Ther, 2005, 12(3): 243-253.
  • 4AGUS DB, BUNN PA JR, FRANKLIN W, et al. HER-2/neu as a therapeutic target in non-small cell lung cancer, prostate cancer, and ovarian cancer[J]. Semin Oncol, 2000, 27(6 Suppl 11): 53-63.
  • 5GREENE FL, COMP TON CC, FRITZ A G, et al. MCC Cancer Staging. Atlas[M]. New York: Springer, 2006: 77-88.
  • 6WOLFF AC, HAMMOND ME, SCHWARTZ JN, et al. American society of clinical oneology/college of American pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer [J]. J Clin Oncol, 2007, 25(1): 118-145.
  • 7LAUDADIO J, QUIGLEY DI, TUBBS R, et al. HER2 testing: a review of detection methodologies and their clinical performance [J]. Expert Rev Mol Diagn, 2007, 7(1): 53-64.
  • 8DREILICH M, WANDERS A, BRATPSTROM D, et al. HER-2 overexpression (3+) in patients with squamous ceU esophageal carcinoma correlates with poorer survival[J]. Dis Esophagus, 2006, 19(4): 224-231.
  • 9AKAMATSU M, MATSUMOTO T, OKA K. C-erbB-2 oncoprotein expression related to chemoradioresistance in esophageal squamous cell carcinoma[J]. Int J Radiat Oncol Biol Phys, 2003, 57(5): 1323-1327.
  • 10SATO S, KAJIYAMA Y, SUGANO M. Monoclonal antibody to HER-2/neu receptor enhances radiosensitivity of esophageal cancer cell lines expressing HER-2/neu oncoprotein [J]. Int J Radiat Oncol Biol Phys, 2005, 61(1): 203-211.

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