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去整合素-金属蛋白酶17与大肠肿瘤发生发展的研究进展

Research Progress of Disintegrin-Metalloproteinase 17 and Tumor Occurrence and Development of Colon
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摘要 目前认为肿瘤发生发展与抑癌基因失活或原癌基因激活有关。另外,缺陷DNA错配修复系统和体细胞突变的迅速积累,导致上皮组织稳态受到凋亡和有丝分裂过程失衡的干扰,凋亡抑制导致增殖增加和基因损害细胞清除减少[1]。众多研究表明多种基因表达产物如转化生长因子-β（transforminggrowthfactor-β,TGF-β）、
作者 曹海龙 罗沈晖
机构地区 天津医科大学总医院消化科
出处 《药品评价》 CAS 2012年第27期13-17,共5页 Drug Evaluation
关键词 大肠肿瘤 去整合素-金属蛋白酶17 进展 Colon tumor Disintegrin-metalloproteinase 17 Progress
分类号 R735.34 [医药卫生—肿瘤]
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2012年 第27期

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