ER及E-Cad在子宫内膜癌组织中的表达及意义研究

The research on the expression of ER and E-Cad in endometrial carcinoma tissue and its clinical significance

目的:探讨雌激素受体(ER)和E-钙黏蛋白(E-Cad)在子宫内膜癌组织中的表达及意义研究。方法:采用Western-blot技术检测子宫内膜癌30例,子宫内膜不典型增生10例,增生期子宫内膜10例标本中ER及E-cad的表达水平,分析二者与不同临床病理指标的关系。结果:(1)ER、E-Cad在子宫内膜癌组织中的阳性表达率明显低于增生期子宫内膜及子宫内膜不典型增生组织,三者比较有显著性差异(P<0.01)。(2)ER、E-Cad在子宫内膜癌中的表达随临床分期增高、组织分化降低、深肌层浸润、有淋巴结转移其阳性表达率呈下降趋势(P<0.01),而与子宫内膜癌患者的年龄无相关性(P>0.05)。结论:在子宫内膜癌中ER和E-cad阳性表达率下降,且二者的表达呈正相关,提示二者共同参与子宫内膜癌变过程,在子宫内膜癌发生中发挥协同作用。

Objective ：To explore the expression of ER and E--cadherin in endometrial carcinoma tissues and its clinical significance. Method：Using Western--blot to detect the ER and E--cadherin protein expressions through 10 cases of endometrial hyperplasia, 10 cases of endometrial atypical hyperplasia specimens and 30 cases of endometrioid adenocarcinoma specimens, moreover, to analyze their correlations with the clinical pathology index. Results： （1）The positive expression rate of ER and E--cadherin in endometrial carcinoma tissue was sig- nificantly lower than that of endometrial hyperplasia and endometrial atypical hyperplasia specimens. （2） ER and E-cadherin in endometrial carcinoma has no relevance to the age of the patients （P 〉 0.05）. The positive expression rate of ER and E--Cad declined when the clinical stages increased, tissue differentiation reduced, deep myometrial invasion and lymph node metastasis in patients with surgery （P 〈 0.01）. Conclusion ：ER and E-cadherin in endometrial carcinomas showed low expression, and ER and E-cadherin expression were posi- tively correlated in endometrial carcinoma; therefore, they may have synergic effects during the endometrial carcinogenesis.