胸腔良恶性积液细胞学与肿瘤标志物联合检测结果分析

Joint detection result analysis of cytology and tumor markers on benign and malignant pleural effusion

目的探讨对胸腔积液进行细胞学与肿瘤标志物联合检查的临床价值。方法选择40例良性肿瘤患者与40例恶性肿瘤患者,比较两组患者细胞学表现与病理学诊断结果以及两组肿瘤标志物检测结果。结果恶性肿瘤组细胞学阳性者占97.5%,诊断符合率为97.5%;良性肿瘤组发生细胞学阳性者占2.5%,误诊率为2.5%,恶性肿瘤组患者癌胚抗原(CEA)、癌抗原125(CA125)、癌抗原153(CA153)和癌抗原199(CA199)水平均显著高于良性肿瘤组(P<0.05)。结论胸腔积液细胞学联合肿瘤学标志物检查是一种无创可重复的方法,为更好的提高临床诊断率提供了一定的帮助。

Objective To investigate the clinic value of joint detection with cytology and tumor markers on pleural effusion.Methods Forty cases of patients with benign tumors and 40 cases of patients with malignant tumors were choosed,the cytology performance,pathology diagnosis,and the result of tumor markers detection in two groups were compared.Results The rate of cytology positive in malignant tumor group was 97.5%,and the diagnosis coincidence rate was 97.5%;the rate of cytology positive in benign tumor group was 2.5%,and the misdiagnosis rate was 2.5%,the carcinoembryonic antigen（CEA）,cancer antigen 125（CA125）,cancer antigen 153（CA153） and cancer antigen 199（CA199） levels in malignant tu mor group were significantly higher than those of benign tumor group（P 0.05）.Conclusion The detection of cytology combined with tumor markers is a noninvasive and repeatable method in checking pleural effusion,and it provides certain help for better improving clinical diagnosis rate.