环氧化酶-2与血管内皮生长因子-C在胆囊腺瘤和胆囊腺癌组织中的表达及临床意义

Expression of cyclooxygenase-2 and vascular endothelial growth factor C and its clinicopathological significance in adenoma and adenocarcinoma of gallbladder MU Hong-ling

目的探讨胆囊良恶性病变组织中环氧合酶-2（COX-2）与血管内皮生长因子-C（VEGF-C）的表达及其临床病理意义。方法采用免疫组织化学法检测44例胆囊腺癌、10例胆囊腺瘤组织中COX-2与VEGF-C的表达。结果胆囊腺癌和胆囊腺瘤组织中COX-2表达阳性率分别为72．7％和40．0％，胆囊腺癌COX-2的表达率明显高于胆囊腺瘤（P〈0．05）。VEGF-C在胆囊腺癌组织中的表达明显高于胆囊腺瘤（63．6％比20．0％，P〈0．05）。COX-2与VEGF-C的表达与胆囊腺癌的Nevin分期和淋巴结转移相关。COX-2与VEGF-C表达显著相关。结论COX-2与VEGF-C表达与胆囊腺癌的发生和生物学行为密切相关。

Objective To study the expression levels of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor C （VEGF-C） and their clinicopathological significance in benign and malignant lesions of gallbladder. Methods The expression levels of COX-2 and VEGF-C were detected by using im- munohistochemistry in 44 cases of gallbladder cancer and 10 cases of gallbladder adenoma. Results The expression rate of COX-2 in gallbladder adenocarcinoma and adenoma was 72.7% % and 40. 0% respec- tively. The expression rate of COX-2 in gallbladder adenocarcinoma was higher than that in gallbladder ade- noma （ P 〈 0. 05）. The expression rate of VEGF-C in gallbladder adenocarcinoma was higher than that in gallbladder adenoma （63.6% vs. 20. 0% ,P 〈0. 05 ）. There was a significant correlation between the ex- pression of COX-2, VEGF-C and Nevin stages and lymph node metastasis of gallbladder carcinoma. There was a significant relationship between COX-2 and VEGF-C. Conclusion The expression of COX-2 and VEGF-C might be closely related to the carcinogenesis and biological behaviors of gallbladder adenocarcino-