参附注射液对腹主动脉瘤开放手术患者机体应激反应的影响

Eeffects of Shenfu injection on stress response in patients undergoing artic aneurysm open operation

目的观察腹主动脉瘤开放手术术中参附注射液对患者应激反应与缺血再灌注损伤的影响。方法选择腹主动脉瘤开放手术的患者50例，随机分成2组，每组各25例。麻醉维持分别采用参附注射液加丙泊酚全凭静脉麻醉组（A组）和单纯丙泊酚全凭静脉麻醉组（B组）。麻醉中监测2组患者的血压和心率，并分别于麻醉诱导前（T1）、气管插管前1min（T2）、气管插管后1min（T3）、切皮后1min（T4）、手术探查（T5）、手术结束（帕）采血测定血浆皮质醇（Cor）、血浆超氧化物歧化酶（SOD）和白细胞介素-6（IL-6）水平。结果A组血压的稳定性优于B组，A组T4的Cor水平（16．3±5．2）较B组T4（21．4±5．4）低；A组％的SOD水平（119．38±11．54）较B组T6（228．21±22．18）低；A组眄的IL-6水平（13．5±1．6）较B组T5（16．9±2．4）低。结论参附注射液能减少腹主动脉瘤开放手术患者机体应激反应与缺血再灌注损伤程度。

Objective To investigate effects of Shenfu Injection on stress response and ischemia- reperfusion injury in patients undergoing artic aneurysm open operation. Methods Fifty patients undergo- ing artic aneurysm open operation were randomly divided into two groups with 25 pepotes in each group. Pepole received Shenfu injection before propofol intravenous anesthesia （group A） or Propofol intravenous anesthesia only （ group B）. Blood pressure and heart rate were observed, and the venous samples were col- lected to detect serum cortisol, superoxide dismutase （SOD） and interleukin-6 （IL-6） before anesthesia （ T1 ）, 1 minlbefore intubation （ T2）, 1 min after intubation （ T3 ）, 1 min after skin incision （ T4）, during surgical expldration （T5） and at the end of surgery （T6）. Results The blood pressure of group A is more stable than that of group B, and T4 Cor （ 16. 3 ± 5.2） in group A is lower T4 in than group B （21.4 ± 5.4） ; T6 SQD （119.38 ±11.54） in group A is lower T6 in than group B （228.21 ±22. 18） ; T6 SOD （ 119. 38 ± 11.54） ; T5 IL-6 （ 13.5 ± 1.6 ） in group A is lower than T5 in group B （ 16. 9 ± 2.4）. Conclu- sion Using Shenfu injection can reduce the stress response and ischemia-reperfusion injury in patients un- dergoing attic aneurysm Open operation.