尿微量白蛋白/肌酐异常人群炎性和代谢类指标的分析

Analyze the Relationship between inFlammation Indicators, Metabolise and the Abnormal Ratio of Microalbumin/Creatinine

目的探讨尿微量白蛋白/肌酐(ACR)异常人群炎性和代谢类指标的改变及影响。方法回顾性分析ACR正常组和异常组生化指标,血细胞和糖化血红蛋白。结果男性中ACR正常组与异常组间存在差异的指标分别有BMI、WBC、LYM%、N%、RBC、HbA1c、hs-CRP、TG和HDL。其中指标HbA1c、BMI、LYM%、N%及TG的异常可增加ACR异常的风险。女性正常组与异常组间存在差异的指标分别有HbA1c、hs-CRP和Un。其中指标HbA1c及Un异常可增加ACR异常的风险。结论 ACR的异常与肾脏功能密切相关,是监测肾脏损害的早期的指标;糖代谢异常、肥胖和脂代谢异常,都是肾脏早期受损的风险因素,hs-CRP作为检测指标可非特异的反映肾脏早期损害;ACR早期检测对预防糖尿病肾病有重要意义。ACR不随年龄变化发生改变。

Objective To investigate the inflammatory indicators and metabolise level among people with abnormal ratio of Microalbumin/ Creatinine.Methods Retrospective analysis of the biochemical indicators,blood corpuscle and glycated hemoglobin of the normal group and the abnormal group of ACR.Results For men,BMI,WBC,LYM%,N%,RBC,HbA1c,hs-CRP,TG and HDL showed significant difference between the normal group and the abnormal group of ACR.For women,HbA1c,hs-CRP and Un showed significant difference between the normal group and the abnormal group of ACR.HbA1c and Un affect the change of ACR.Conclusion The abnormal ACR is related to the renal function.They are also the early biomarkers for monitoring renal damage.HbA1c is the abnormal risk factor of Microalbumin/Creatinine and it is further explain that ACR is the sensitivity indicator for testing in early stage.