阿卡波糖治疗葡萄糖调节受损患者的临床疗效观察

Clinical Effects in Cases of Impaired Glucose Regulation Treated with Acarbose

目的探讨阿卡波糖治疗葡萄糖调节受损患者(Impaired glucose regulation,IGR)的临床疗效。方法将初诊88例IGR患者随机分为对照组42例,治疗组46例,对照组仅给予强化饮食和运动教育治疗,治疗组在此基础上给予阿卡波糖治疗。16周后观察患者治疗前后体质量指数(Body mass index,BMI)、空腹血糖(Fasting blood glucose,FBG)、口服糖耐量试验2h血糖(2h blood glucose duringoral glucose tolerance test,2hPBG)、胆固醇(Total cholesterol,TC)、三酰甘油(Triglyceride,TG)、C反应蛋白(C-reactive protein,CRP)的变化。结果对照组、治疗组患者干预后BMI、FBG、2hPBG、TG均较干预前降低(P<0.05)。且治疗组患者FBG、P2hBG降低较对照组明显(P<0.05)。对照组患者CRP治疗前较治疗后略有降低(P>0.05),治疗组CRP治疗前较治疗后明显降低(P<0.05)。结论阿卡波糖可以改善IGR患者的糖代谢及微炎症状态。

Objective To investigate clinical effects in cases of impaired glucose regulation（IGR） treated with acarbose.Methods 88 IGR patients were divided into control group（diet＋exercise） and treat group（diet＋exercise＋acarbose） randomly.To obserse changes before and after treatment include body mass index（BMI）,fasting blood glucose（FBG）,2h blood glucose during oral glucose tolerance test（2hPBG）,total cholesterol（TC）,triglyceride（TG）,Creactive protein（CRP）.Results After treatment,BMI,FBG,2hPBG、TG of Two groups patients dropped and this change was significant treat group than control group（P〈0.05）.After treatment,CRP of control group lightly dropped（P〉0.05） and CRP of treat group significantly dropped（P〈0.05）.Conclusions Acarbose significantly improve glucose metabolism and small imflammation condition of IGR patients.