利奈唑胺用于白血病患者化疗后感染的疗效观察

Clinical Effect Observation on Infection After Chemotherapy of Linezolid Applied for Patients with Leukemia

目的观察利奈唑胺用于白血病患者化疗后感染的疗效与安全性。方法选择我院2011年6月至2012年12月21例白血病化疗后感染患者给予利奈唑胺静脉滴注,本组患者设为观察组,同时选择21例采用头孢曲松治疗的患者作为对照组,对两组治疗效果、致病菌清除率及不良反应进行比较。结果观察组痊愈14例,显效5例,总有效率为95.24%;对照组痊愈6例,显效10例,总有效率为76.19%;两组比较差异具有显著性,有统计学意义P<0.05。比较两组细菌清除率,观察组清除20例,细菌清除率为95.24%;对照组清除16例,细菌清除率为76.19%,两组比较差异具有显著性,有统计学意义P<0.05。观察组未见不良反应病例,对照组出现1例皮肤瘙痒,两组不良反应比较差异无显著性,无统计学意义P>0.05。结论利奈唑胺治疗白血病化疗后感染具有疗效好,副反应少的优点,可作为临床的首选。

Objectives To observe the clinical effect and safety of infection after chemotherapy of linezolid applied for patients with leukemia.Methods 21 patients with leukemia treated in our hospital from June 2011 to December 2012 were given linezolid intravenously after chemotherapy and were named as the observation group.During the same time,21 patients treated with Qu Song were selected as the control group.Comparing the treatment effect,pathogen clearance rate and adverse reactions of 2 groups.Results In the observation group,14 cases were cured and 5 cases were effective,the total effective rate was 95.24%.As for the control group,6 cases were cured and 10 patients were effective,the total effective rate was 76.19%.There was significant difference between 2 groups,which had statistical significance P〈0.05.As for the pathogen clearance rate of 2 groups,20 cases were removal in the observation group and the pathogen clearance rate was 95.24%,and 16 cases were removal in the control group and the the pathogen clearance rate was 76.19%.There was evident difference between 2 groups,which had statistical significanceP〈0.05.There was no adverse reaction in the observation group and there was 1 case of cutaneous pruritus in the control group,and there was no significant difference between 2 groups as for the adverse reaction,which had no statistical significance P〉0.05.Conclusions Linezolid applied for patients with leukemia after chemotherapy has the advantages of good clinical effect and little adverse reaction,which can be as the clinical choice.