A型肉毒毒素注射治疗26例手多汗症的临床观察

Botulinum toxin type A for the treatment of palmar hyperhidrosis:a prospective study of 26 patients

手多汗症是指发生于手掌的过多的出汗,给造成社交和就业上的困难。本研究对A型肉毒毒素治疗手多汗症的疗效进行临床观察。选择26例手多汗症患者(女17例,男9例),参照多汗症量表评估其出汗严重程度。记录患者A型肉毒毒素注射前后出汗评分、起效时间、副作用等指标。结果发现A型肉毒毒素注射后手出汗明显减少,效果持续3个月以上,而且副作用轻微且一过性。A型肉毒毒素注射治疗手多汗症是安全、有效的实用方法。

Palmar hyperhidrosis is characterized by excessive sweating in hand,it has a significant impact on the social and profession- al relationships of affected individuals.The aim of this study was to assess effect of botulinum toxin type A （BTX-A） to patients with palmar hyperhidrosis.The study included 26 patients （17 women and 9 men） with a diagnosis of Palmar hyperhidrosis treated with BTX-A. severity of hyperhidrosis qualitative measured by The Hyperhidrosis Disease Severity Scale （HDSS）. All patients completed a questionnaire included the following information： time to effect of BTX-A; local or systemic side effects; and severity of hyperhidrosis before and after BTX-A treatment.There was a highly significant reduction in the severity of hyperhidrosis 3 months after performing the treatment with BTX-A. The side effects of treatment were sligtht and short. Treatment of Palmar hyperhidrosis with BTX-A was well tolerated and effective.