布地奈德混悬液雾化吸入治疗小儿轻中度喉炎疗效观察

Observation on efficacy of nebulized budesonide suspension inhalation in treatment of mild to moderate laryngitis in children

目的:探讨布地奈德混悬液治疗小儿急性喉炎的临床疗效。方法:将60例急性喉炎患儿随机分为观察组和对照组各30例。两组均给予积极抗感染、吸氧、补痰、化痰、止咳对症等治疗。两组中若出现Ⅱ度喉梗阻患儿均给予静脉注射地塞米松。观察组在常规治疗基础上给予布地奈德混悬液雾化吸入;对照组在常规治疗基础上给予地塞米松注射液雾化吸入。观察两组患儿症状、体征消失时间、住院时间及不良反应情况。结果:观察组总有效率明显高于对照组(P<0.05);观察组症状和体征消失时间均低于对照组(P<0.05)。结论:布地奈德混悬液雾化吸入治疗小儿急性喉炎具有疗效好、见效快、不良反应少等优点,值得临床推广应用。

Objective To investigate the clinical efficacy of nebulized budesonide suspension inhalation on the children with mild to mod- erate laryngitis. Methods： Sixty children with acute laryngitis were randomly divided into two groups. 30 cases in the treatment group were treated with nebulized budesonide suspension inhalation and routine treatment, which including anti-infectious drugs and oxy- gen, et al. And the control group were taken dexamethasone injection aerosol inhalation except the routine treatment. When the two groups have II degree laryngeal obstruction would be taken dexamethasone （i.v.）. The symptoms and the days of elimination of the signs and the adverse reactions were observed. Results： The total effective rate and the days of elimination of the symptoms and signs in the treatment group were better than those in the control group （p〈0.05）. Conclusion： For the children with mild to moderate laryngitis, Nebulized budesonide inhalation has better clinical efficacy and safety ,so it is worthy of clinical application.