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消渴安胶囊和阿卡波糖对糖耐量减低患者空腹血糖及糖耐量的影响 被引量:1

Effect of Xiaoke'an Capsule and Acarbose on glucose tolerance in patients with impaired fasting glucose and glucose tolerance
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摘要 目的探讨消渴安胶囊和阿卡波糖治疗糖耐量减低(IGT)患者的临床疗效及安全性。方法对2005年6月~2011年12月我院收治的IGT患者的临床资料进行回顾性分析,根据用药方法的不同分为观察组(92例)和对照组(114例),观察组口服中药消渴安胶囊治疗,对照组口服阿卡波糖治疗。治疗6个月后观察两组的临床疗效及不良反应情况。结果经过6个月的治疗,观察组有效77例,无效15例,有效率为83.7%。对照组有效95例,无效19例,有效率为83.3%,两组疗效相当(P>0.05)。两组治疗后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、三酰甘油(TG)、空腹胰岛素(FINS)、餐后2 h胰岛素(2 h INS)及HOMA-IR评分较治疗前均明显减低(P<0.05或P<0.01),但两组治疗后比较差异无统计学意义(P>0.05)。对照组患者在治疗过程中不良反应发生率为64.9%,观察组无不良反应事件发生。结论应用消渴安治疗IGT能达到与阿卡波糖片同样的治疗效果,同时经济、安全,值得临床推广应用。 Objective To investigate the clinical efficacy and safety of impaired glucose tolerance patients treating with Xiaoke'an Capsule and Acarbose.Methods The clinical data of patients with impaired glucose tolerance admitted to our hospital from June 2005 to December 2011 was analyzed retrospectively,according to the different treatment methods,they were divided into the observation group and the control group,the observation group was treated with Xiaoke'an Capsule,the control group was treated with Acarbose.After 6 months of treatment,the therapeutic effect and adverse reaction of the two groups were observed.Results After 6 months of treatment,77 cases were treated effectively in the observation group,15 cases were invalid,the effective rate was 83.7%.95 cases were treated effectively in the control group,19 cases were invalid,the effective rate was 83.3%,the curative effect of the two groups was considerable(P0.05).After treatment,the FPG,2 h PG,TG,FINS,2 h INS and HOMA-IR score of the two groups were significantly lower than the treatment before(P0.05 or P0.01),but after treatment,there were no significant differences in the two groups(P0.05).The adverse reactions occurring rate of the control group during treatment was 64.9%,the observation group had no adverse reactions.Conclusion IGT treated with Xiaoke'an has the same therapeutic effect compared with Acarbose Tablets,and it is economy,safety,and worthy of clinical application.
作者 覃俏峰
出处 《中国医药导报》 CAS 2012年第29期101-102,105,共3页 China Medical Herald
关键词 消渴安胶囊 阿卡波糖 糖耐量 血糖 Xiaoke'an Capsule Acarbose Glucose tolerance Blood glucose
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