中医药与中西医结合对比西药治疗2型糖尿病随机对照试验的Meta分析

Meta Analysis on Randomized Controlled Study Comparing Traditional Chinese Medicine and Integrative Medicine with Western Medicine in the Treatment of Type 2 Diabetes

目的:系统评价单纯中医药与中西医结合对比西药治疗2型糖尿病的临床效果,包括总有效率、空腹血糖、总胆固醇及甘油三酯等结局指标,为临床用药决策提供科学依据。方法:通过对CNKI全文数据库、Google学术搜索、Medline、Cochrane database等数据库的检索,对符合纳入标准的文献进行JADAD质量评价,随后进行异质性检验和Meta分析,并进行敏感度分析及绘制漏斗图。结果:单纯中医药与西药治疗糖尿病的临床疗效无显著性差异;中西药结合治疗糖尿病的临床疗效显著优于西药治疗组。结论:Meta分析结果提示,中西医结合治疗2型糖尿病与西药比较有其优势,但由于纳入研究质量低、试验方法学质量尚不高,结果仍需更多的多中心、大样本、设计良好的随机对照试验来验证。

Objective ： TSystematic review of clinical effects including the total effective rate, fasting glucose, total cholesterol and triglycerides of Chinese medicine, integrative medicine and western medicine on treatment of type 2 diabetes, For provide scientific basis for clinical decision-making. Methods ： I electronically searched Full-text database CNKI, Google Scholar, Medline, Cochrane Database and other database, made JADAD quality assessment which met the inclusion criteria, and subsequent make heterogeneity test, Metaoanalysis, sensitivity analysis, and draw the funnel plot. Results ： There was no significant difference between traditional Chinese medicine and western medicine in clinical efficacy in the treatment of diabetes ; however, the diabetic patients treated with integrated medicine showed much better efficacy than those treated with western medicine alone. Conclusion ： Meta-analysis told the treatment of type 2 diabetes with integrative medicine has more advantages, however, this conclusion remains to be confirmed further by more and more large sample, well-designed randomized controlled trials given the low quality researches and test methodology.