尼莫地平对急性高血压性脑出血的疗效观察与评价

Evaluation of the effect of Nimodipine in patients with acute cerebral hemorrhage

目的:评价尼莫地平治疗急性脑出血的疗效。方法:采用随机、对照实验方法。180例确诊为急性脑出血患者作为研究对象。随机分为两组,即尼莫地平治疗组(T组)和对照组(C组)。T组在常规治疗的基础上予以尼莫地平16mg加入生理盐水500mL微量泵静脉输注,连续应用14天。比较两组治疗前、治疗7天、14天的血肿量及治疗1个月、3个月后神经功能缺损程度评分。结果:T组与C组比较血肿量治疗7天、14天T组低于C组,有统计学差异。治疗1个月、3个月后神经功能评分,T组高于C组,有统计学差异(p<0.05)。结论:尼莫地平能减少脑出血患者血肿量和血肿周围的水肿面积并可促进脑出血患者的神经功能康复。

Objective ： To investigate effect of Nimodipine in patients with acute cerebral hemorrhage. Methods ： 180 patients with acute cerebral hemorrhage were divided into control group （C group）and Nimodipine treatment group （T group） randomly. The patients in T group additionally received Nimodipine injection by micro pump for 14 days on basis of general therapy, while those in C group received conventional therapy alone.Two groups were scored on neurelogic impairment and compared before treatment, 7 days, 14 days, 1 month, 3 months after treatment. Results ： The volume of hematoma and perilesional edema of the patients in T group was decreased significantly when compared to C group at days 7 and 14 after the treatment, 1 month and 3 months later, T group differed significantly from C group in the neurolagic impairment score （P 〈0.05）. Conclusion ： Nimodipine can facilitate neurologic rehabilitation of cerebral hemorrhage patients.