全氟化合物发育神经毒性研究进展

Research Progress in Developmental Neurotoxicity of Perfluorinated Compounds

全氟化合物(PFCs)在工业生产和生活中广泛应用,已成为环境中一类普遍的污染物。由于PFCs污染表现出全球性、持久性和富集性等特征,其毒性备受关注。近期研究结果显示,PFCs除对肝脏、免疫系统和生殖内分泌系统等有明显影响外,还具有发育神经毒性。在总结了近年来PFCs发育神经毒性的研究进展基础上,讨论了PFCs发育神经毒性可能的几个机制,并且分析该领域研究存在的问题,提出应该加强环境相关剂量下PFCs发育神经毒性研究,关注PFCs与其他神经毒物复合暴露的发育神经毒性,以推进对实际环境中PFCs所产生的神经损伤的认识。

Widely used in industrial production and life, some of the perfluorinated compounds （PFCs） have become a class of ubiquitous pollutants in the environment. Due to globally distribution, environmentally per- sistence and bioaccumulation of PFCs, the toxicity of PFCs has raised increasing concern. Recent resuks of study show that PFCs have developmental neurotoxicity besides significant toxicity on the liver, immune, re- productive and endocrine systems. In this paper, the research progress in developmental neurotoxicity of PF- Cs in recent years were outlined, and the several mechanisms of PFCs developmental neurotoxicity of PFCs were discussed. Additionally, the problems in the future research in this field were analyzed. To promote the further understanding of neural damages of PFCs in the real environment, it was suggested that research in developmental neurotoxieity of PFCs at environmental relevant dose should be strengthened. The develop- mental neurotoxicity induced by combined exposure to PFCs and other neurotoxicants should be concerned.