度洛西汀合并小剂量喹硫平治疗伴躯体症状抑郁症的对照研究

Observation of duloxetine combined with small dose of quetiapine in the treatment of depression with somatic symptoms

目的评价度洛西汀合并小剂量喹硫平治疗伴躯体症状抑郁症的疗效和安全性。方法将68例伴躯体症状的抑郁症患者随机分为2组,对照组单用度洛西汀治疗,试验组度洛西汀合并小剂量喹硫平治疗,治疗8周。治疗前,治疗后1,2,4,8周用汉密尔顿抑郁量表(HAMD-24)评定疗效及药物副反应量表(TESS)评定不良反应。结果试验组有效率94.1%,明显高于对照组的76.5%,差异有统计学意义(P<0.05)。合并喹硫平后无力、困倦等不良反应增加,但多在1周内减轻。结论度洛西汀合并小剂量喹硫平治疗伴躯体症状抑郁症可提高有效率,叠加的不良反应轻微。

Objective To explore the efficacy and safety of duloxetine combined with small dose of quetiapine in the treatment of depression with somatic symptoms. Methods Sixty - eight cases of depression with somatic symptoms were randomly divided into two groups, one group was treated with duloxetine, and the other was treated with duloxetine com- bined with small dose of quetiapine. Treatment for before treatment and after 1, 2, 4, 8 weeks,the efficacy and safety were evaluated with Ham- ilton Depression Scale - 24 （ HAMD - 24 ） and Treatment Emergent Symptom Scale （TESS）. Results The effect rate in the research group was 94. 1% , higher than that of the control group of 76.5%, which of two groups had significant difference. Side effects increased after treating with quetiapine, but loss within a week, such as weakness, drowsiness. Conclusion Duloxetine combined with small dose of quetiapine in the treatment of depression with somatic symptoms can improve the efficiency and side effects of treatment are mild.