血必净注射液辅助治疗脓毒症的疗效观察

Observation on effect of Xuebijing injection in adjunctive therapy of sepsis

目的评价血必净注射液辅助治疗脓毒症的临床疗效。方法将64例脓毒症患者随机分为治疗组和对照组,每组32例,对照组按常规治疗,治疗组在常规治疗基础上加用血必净注射液50 mL静脉滴注,2次/d,连用8 d;观察两组治疗前后白细胞计数(WBC)、中性粒细胞比例(N)、体温(T)、心率(HR)、呼吸频率(RR),以及血清降钙素原(PCT)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白介素6(IL-6)水平,比较两组的显效率和总有效率。结果两组患者治疗后各项指标均较治疗前明显降低(P<0.01);治疗组WBC、N、T、HR、RR、PCT、CRP、TNF-α、IL-6水平明显低于对照组(P<0.05),显效率、总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论血必净注射液能够改善脓毒症患者的临床症状,提高疗效。

【Objective】 To evaluate the clinical efficacy of Xuebijing injection in the adjunctive therapy of sepsis.【Methods】 64 patients with sepsis were randomly divided into two groups.32 patients in the control group were given conventiona1 therapy.32 patients in experimental group were given 50 mL Xuebijing injection through intravenous drip twice a day for 8 days.White blood cell count（WBC）,neutrophil ratio（N%）,body temperature（T）,heart rate（HR） and respiration rate（RR） were observed,and the levels of serum procalcitonin（PCT）,C-reactive protein（CRP）,tumor necrosis factor-α（TNF-α） and interleukins-6（IL-6） were detected in two groups before and 8 days after treatment.The excellence rate and total effective rate were compared in the two groups.【Results】 Compared with pretherapeutic indicators,those in the two groups after treatment significantly decreased（P 0.01）.WBC,N,T,HR,RR,PCT,CRP,TNF-α and IL-6 in the experimental group were significantly lower than those in the control group（P 0.05）.The excellence rate and total effective rate in the experimental group were markedly higher than those in the control group（P 0.05）.【Conclusion】 Xuebijing injection can relieve the clinical symptoms in the septic patients with the improved effect.