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凋亡抑制蛋白在胶质瘤治疗中的应用研究进展 被引量：3

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摘要 作为细胞内细胞凋亡抑制作用最强的蛋白质家族之一，凋亡抑制蛋白（inhibitor of apoptosis proteins，IAPs）被认为参与了肿瘤的发生发展．并在肿瘤抵抗放化疗过程中扮演重要角色。
作者 刘磊 陈维平 黄玮
机构地区 广西医科大学第一附属医院神经外科 广西医科大学组织学与胚胎学教研室
出处 《实用医学杂志》 CAS 北大核心 2012年第21期3668-3670,共3页 The Journal of Practical Medicine
关键词 凋亡抑制蛋白 胶质瘤 APOPTOSIS 应用 治疗 蛋白质家族 抑制作用 细胞凋亡
分类号 R739.4 [医药卫生—肿瘤]
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参考文献19

  • 1Fulda S, Vucic D. Targeting IAP proteins for therapeutic intervention in cancer [J]. Nat Rev Drug Discov, 2012,11 (2) : 109-124.
  • 2Vaux D L, Silke J. IAPs, RINGs andubiquitylation [J]. Nat Rev Mol Cell Biol, 2005,6(4) : 287-297.
  • 3Blankenship J W, Varfolomeev E, Goncharov T, et al. Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1) [J]. Siochem J, 2009, 417( 1 ) : 149-160.
  • 4Pennati M, Millo E, Gandellini P, et al. RNA interference-mediated valida- tion of survivin and Apollon/BRUCE as new therapeutic targets for cancer therapy [J]. Curr Top Med Chem, 2012,12(2) :69-78.
  • 5Cartier J, Marivin A, Berthelet J, et al. IAPs: a central element in the NF- kappaB activating signaling pathway [J]. ned Sci (Paris), 2012,28(1): 69-75.
  • 6Wang P, Zhen H, Zhang J, et al. Survivin promotes glioma angiogenesis through vascular endothelial growth factor and basic fibroblast growth factor in vitro and in vivo [J]. Mol Carcinog, 2012,51 (7) : 586-595.
  • 7Shirai K, Suzuki Y, Oka K, et al. Nuclear survivin expression predicts poorer prognosis in glioblastoma [J]. J Neurooncol, 2009,91 (3) : 353-358.
  • 8Shankar S L, Mani S, O'Guin K N, et al. Survivin inhibition induces human neural tumor cell death through caspase-independent and dependent pathways [J]. J Neurochem, 2001,79 ( 2 ) : 426-436.
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  • 10Yuan B, Ran B, Wang S, et al. siRNA directed against Livin inhibits tumor growth and induces apoptosis in human glioma cells [J..l Neurooncol, 2012,107( 1 ) : 81-87.

同被引文献40

  • 1李家亮,于春江.岛叶低级别胶质瘤的显微外科治疗[J].中华神经外科杂志,2006,22(6):364-365. 被引量：32
  • 2Fan X,Mikolaenko I,Elhassan I. Notchl and notch2 have opposite effects on embryonal brain tumor growth[J].Cancer Research,2004,(21):7787-7793.
  • 3Kuhnert F,Kirshner JR,Thurston G. Dll4-Notch signaling as a therapeutic target in tumor angiogenesis[J].Vascular Cell,2011,(01):20.
  • 4Xu P,Qiu M,Zhang Z. The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo[J].Journal of Neuro-Oncology,2010,(01):41-51.
  • 5Kunnakkat S,Mathew M,Narayana A. Antiangiogenic therapy in the management of brain tumors:a clinical overview[J].Cancer Chemotherapy and Pharmacology,2012,(03):353-363.
  • 6Wang Z,Li Y,Banerjee S. Exploitation of the Notch signaling pathway as a novel target for cancer therapy[J].Anticancer Research,2008,(6A):3621-3630.
  • 7Koch U,Radtke F. Notch signaling in solid tumors[J].Current Topics in Developmental Biology,2010.411-455.
  • 8Won HY,Lee JY,Shin DH. Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway[J].Federation of American Societies for Experimental Biology,2012,(12):5002-5013.
  • 9Seke Etet PF,Vecchio L,Nwabo Kamdje AH. Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells:any role for Notch,Wnt and Hh signaling pathways[J].Cellular Signalling,2012,(07):1433-1443.
  • 10Lamy S, Moldovan PL, Ben Saad A, et al. Biphasic effects of luteolin on interleukin-113-induced cyclooxygenase-2 expression in? glioblas- toma cells[J]. Biochim Biophys Acta,2014,1853 (1) :126-135.

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实用医学杂志
2012年 第21期

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