摘要
目的:观察桃红四物汤预防胫骨骨折髓内钉内固定术后下肢深静脉血栓(DVT)发生的临床疗效。方法:将89名患者随机分成2组,治疗组43例,口服桃红四物汤150mL,每天2次,连续7d;对照组46例,皮下注射低分子肝素钙4000U,每天1次,连续7d。术后1周B超检查下肢血栓,观察DVT的发生率,检测血浆内皮素(ET)含量,统计日平均费用。结果:2组间DVT发生率无明显差异(P>0.05),但治疗组的抗凝日平均费用显著低于对照组(P<0.05);2组术后第14天血浆ET含量均较术后第3天显著下降(P<0.05),且治疗组显著低于对照组(P<0.05)。结论:桃红四物汤能有效预防胫骨髓内钉内固定术后DVT的发生,且治疗费用低廉。
OBJECTIVE:To observe the clinical efficacy of Taohong siwu tang to prevent formation of deep vein thrombosis(DVT) in patients with tibial fractures after intramedullary nailing fixation.METHODS:89 patients were randomly divided into treatment group(43 patients,Taohong siwu tang 150 mL,po,twice a day,consecutive 7 days) and control group(46 patients,hypodermic injection of low molecular weight heparin 4 000 U once a day,consecutive 7 days).1 week later,vein thrombosis of lower extremities was detected by B ultrasound,the incidence of DVT,plasma level of ET and DDC were observed and determined.RESULTS:The incidence of DVT had no significant difference between 2 groups(P0.05) and average daily cost of anticoagulation in treatment group was significantly lower than control group(P0.05).The plasma levels of ET in 2 groups 14 days after operation was significantly lower than 3 days after operation(P0.05),and the plasma level of ET in treatment group was significactly lower than control group(P0.05).CONCLUSION:Taohong siwu tang can effectively prevent the occurrence of DVT after intramedullary nailing fixation of tibial fracture and cost less.
出处
《中国药房》
CAS
CSCD
2012年第43期4103-4105,共3页
China Pharmacy
关键词
桃红四物汤
胫骨骨折
髓内钉
下肢深静脉血栓
Taohong siwu tang
Tibial fractures
Intramedullary nailing
Deep vein thrombosis of lower extremities