桃红四物汤预防胫骨骨折髓内钉内固定术后下肢深静脉血栓发生的临床观察

Efficacy Observation of Taohong Siwu Tang for the Prevention of Deep Vein Thrombosis after Intramedullary Nailing Fixation of Tibial Fractures

目的:观察桃红四物汤预防胫骨骨折髓内钉内固定术后下肢深静脉血栓(DVT)发生的临床疗效。方法:将89名患者随机分成2组,治疗组43例,口服桃红四物汤150mL,每天2次,连续7d;对照组46例,皮下注射低分子肝素钙4000U,每天1次,连续7d。术后1周B超检查下肢血栓,观察DVT的发生率,检测血浆内皮素(ET)含量,统计日平均费用。结果:2组间DVT发生率无明显差异(P>0.05),但治疗组的抗凝日平均费用显著低于对照组(P<0.05);2组术后第14天血浆ET含量均较术后第3天显著下降(P<0.05),且治疗组显著低于对照组(P<0.05)。结论:桃红四物汤能有效预防胫骨髓内钉内固定术后DVT的发生,且治疗费用低廉。

OBJECTIVE：To observe the clinical efficacy of Taohong siwu tang to prevent formation of deep vein thrombosis（DVT） in patients with tibial fractures after intramedullary nailing fixation.METHODS：89 patients were randomly divided into treatment group（43 patients,Taohong siwu tang 150 mL,po,twice a day,consecutive 7 days） and control group（46 patients,hypodermic injection of low molecular weight heparin 4 000 U once a day,consecutive 7 days）.1 week later,vein thrombosis of lower extremities was detected by B ultrasound,the incidence of DVT,plasma level of ET and DDC were observed and determined.RESULTS：The incidence of DVT had no significant difference between 2 groups（P0.05） and average daily cost of anticoagulation in treatment group was significantly lower than control group（P0.05）.The plasma levels of ET in 2 groups 14 days after operation was significantly lower than 3 days after operation（P0.05）,and the plasma level of ET in treatment group was significactly lower than control group（P0.05）.CONCLUSION：Taohong siwu tang can effectively prevent the occurrence of DVT after intramedullary nailing fixation of tibial fracture and cost less.