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MicroRNA与脂肪代谢 被引量：3

MicroRNA and lipid metabolism
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摘要 MicroRNA(miRNA)是一种非编码的小分子RNA,在基因的表达调控过程中起着非常重要的作用。近几年的研究表明,miRNA的表达与人类脂肪组织分布有关,它不但降低脂代谢相关基因的表达,而且抑制脂代谢相关通路(如Wnt通路),并在脂肪细胞的分化以及脂代谢的调节中发挥重要作用,其水平的变化可导致相应的脂质代谢紊乱及肥胖症等疾病的产生,从而可能成为新的药物设计和治疗靶点。 MicroRNAs（miRNAs） are small,non-coding regulatory RNAs,which play important roles in the regulation of gene expression.Recent studies indicate that the expression of miRNAs is closely related with the distribution of adipocyte tissues,which not only downregulates the gene expression of lipid metabolism but also inhibits the signal pathway of fat metabolism such as Wnt pathway,and contributes to the adipocyte differentiation or lipid metabolism.The change of miRNAs expression level could lead to lipid metabolism disorder and obesity.Therefore,miRNAs are emerging as novel therapeutic targets for obesity.
作者 刘雅青 周后德
机构地区 中南大学湘雅二医院代谢内分泌研究所
出处 《国际病理科学与临床杂志》 CAS 2012年第5期416-420,共5页 Journal of International Pathology and Clinical Medicine
基金 国家自然科学基金(81070278) 湖南省杰出青年基金项目(100JJ1007)~~
关键词 微小RNA 脂肪代谢 代谢病 microRNA lipid metabolism metabolic syndrome
分类号 R363 [医药卫生—病理学]
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参考文献28

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二级参考文献59

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共引文献17

同被引文献80

  • 1严治涛,李南方.棕色脂肪的来源及形成研究进展[J].中国医学科学院学报,2009,31(6):778-781. 被引量：6
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引证文献3

二级引证文献4

国际病理科学与临床杂志
2012年 第5期

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