XIAP、P53和Ki67在甲状腺乳头状癌中的表达及相互关系

Expression and relationship of XIAP, P53 and Ki67 in papillary thyroid carcinoma

目的探讨XIAP、P53和Ki67在甲状腺乳头状癌组织中的表达及相互关系。方法采用免疫组化SP法检测35例甲状腺乳头状癌和28例甲状腺腺瘤组织中XIAP、P53和Ki67的表达情况。结果 XIAP、P53和Ki67在甲状腺乳头状癌组织中表达阳性率分别为94.29%、85.71%和65.71%,与甲状腺腺瘤(50.00%、14.29%、7.14%)比较差异有统计学意义(P<0.01)。P53和Ki67的表达与XIAP的表达无相关性(r值分别为0.05177和0.02457,P均>0.05)。P53和Ki67在甲状腺乳头状癌组织中的表达与性别、年龄、结节数量、肿瘤大小无关(P>0.05),XIAP表达女性高于男性。结论 XIAP、P53和Ki67在甲状腺乳头状癌组织中表达增高,XIAP、P53和Ki67表达无相关关系。

Objective To investigate the expression of X-linked inhibitor of apoptosis protein （XIAP）, P53 and Ki67 and analyze their relationship with papillary thyroid carcinoma. Methods Immunohistochemical method （S-P） was used to detect the expression of XIAP, P53, Ki67 in 35 cases of papillary thyroid carcinoma and 28 cases of thyroid ade- noma. Methods Immunohistochemical method （S-P） was used to detect expression of XIAP, P53, Ki67 in 35 cases of papillary thyroid carcinoma and 28 cases of thyroid adenoma. Results The positive expression rates of XIAP, P53, Ki67 were 94.29%, 85.71%, 65.71% respectively in papillary thyroid carcinoma, which were significantly higher than those in thyroid adenoma （50.00% ,14.29% ,7.14%, P 〈 0.01）. The expression of P53, Ki67 were not related with that of XIAP （r = 0,05177,0.02457, P 〉 0.05）. The expression of P53, Ki67 were not correlated with patients sex, age, number of nod- ules tumor size in papillary thyroid carcinoma （P 〉 0.05）, and the expression of XIAP in female was higher than that in male. Conclusions The expressions of XIAP, P53, Ki67 are increased in papillary thyroid carcinoma. However, the ex- pression of P53, Ki67 is not correlated with that of the XIAP.