期刊文献+

钼和汞联合染毒对小鼠骨髓多染红细胞微核率影响 被引量:1

Effects of Joint Exposure to Molybdenum and Mercury on Micronucleus Rate of Bone Merrow Polychromatic Erythrocyte of Mice
下载PDF
导出
摘要 [目的 ]探讨钼对汞遗传毒性的影响。 [方法 ]观察采用腹腔注射钼酸钠和氯化汞联合染毒对小鼠骨髓多染红细胞微核率的影响。 [结果 ]连续 4天给小鼠注射 Hg Cl2 〔1.0 mg/ kg (bw)〕的同时注射 10、 10 0 mg/ kg(bw)〕的 Na2 Mo O4可显著降低 Hg Cl2 的致小鼠微核率 (P<0 .0 0 1) ;在 Hg Cl2 〔1.0 mg/ kg (bw)〕给小鼠染毒前 3天连续注射 10 0 mg/ kg(bw) Na2 Mo O4可显著地降低 Hg Cl2 所致微核率 ;在 Hg Cl2 〔1.0 mg/ kg(bw)〕给小鼠染毒后连续 3天注射 Na2 Mo O4,Hg Cl2 致微核率下降不显著 (P>0 .0 5 )。 [结论 Objective]To explore the antitoxic effects of molybdenum on genotoxicity of mercury [Methods]The micronucleus rates of bone merrow polychromatic erythrocytes (BWPCE) of mice jointly exposed to sodium molybdate(Na 2MoO 4) and mercuric chloride(HgCl 2) by intraperitoneal injection were determined [Results]The micronucleus rates of bone merrow polychromatic erythrocytes significantly decreased after 4 day continuous exposure to HgCl 2〔1 0 mg/kg(bw)〕,simultaneously added with different doses of Na 2MoO 4〔10 mg/kg(bw),100 mg/kg(bw) and 100 mg/kg(bw)〕 respectively ( P<0 001 ) The micronucleus rates of BMPCE of mice,with a 3 day continuous pretr eatment with 100 mg/kg(bw) Na 2MoO 4 before exposure to 1 0 mg/kg(bw) HgCl 2,significantly decreased No significant decrease of micronucleus rates of BMPCE was observed in mice with a 3 day continuous exposure to Na 2MoO 4 after pretreatment with 1 0 mg/kg(bw) HgCl 2 ( P>0 05 ) [Conclusion]Molybdenum presented antagonism on the genotoxicity of mercury
出处 《环境与健康杂志》 CAS CSCD 北大核心 2000年第4期208-209,共2页 Journal of Environment and Health
关键词 拮抗作用 钼汞联合染毒 骨髓多染红细胞微核率 Sodium Molybdate Antagonism Mercuric chloride Micronucleus Mice
  • 引文网络
  • 相关文献

参考文献2

  • 1顾祖维主编.劳动卫生学进展.第3卷,北京:人民卫生出版社,1986.142.
  • 2Yasuhiro. Protective effect of molybdenum on the acute toxicity of mercuric chloride. Toxical. Appl. Pharmacol. 1982,62 : 214.

同被引文献26

引证文献1

二级引证文献6

;
使用帮助 返回顶部