期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Sirt3在心肌保护方面的研究进展 被引量：4

下载PDF
导出
摘要 Sirt3是NAD依赖的去乙酰酶，是目前认为其高表达和人类长寿唯一有关的蛋白。Sirt3除了与延缓衰老密切相关外，还具有心肌保护作用。本文对Sirt3的心肌保护作用及其机制进行综述，并提出未来可能的相关研究。
作者 邬云斌 刘新伟 刘玲
机构地区 重庆医科大学附属第一医院麻醉科 湖南省吉首市人民医院麻醉科
出处 《临床麻醉学杂志》 CAS CSCD 北大核心 2012年第10期1024-1025,共2页 Journal of Clinical Anesthesiology
关键词 心肌保护作用 延缓衰老 去乙酰 NAD
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献13

  • 1Pillai VB,Sundaresan NR,Jeevanandam V,et al_ Mitochon-drial SIRT3 and heart disease. Cardiovasc Res, 2010,88(2):250-256.
  • 2Ahn BH, Kim HS, Song S, et al. A role for the mitochondrialdeacetylase Sirt3 in regulating energy homeostasis. Proc NatlAcad Sci USA,2008, 105(38): 14447*14452.
  • 3Lombard DB,Tishkoff DX,Bao J. Mitochondrial sirtuins inthe regulation of mitochondrial activity and metabolic adapta-tion. Handb Exp Pharmacol, 2011, 206 ; 163-J88.
  • 4Cimen H,Han MJ, Yang Y, et al. Regulation of succinatedehydrogenase activity by SIRT3 in mammalian mitochondri-a. Biochemistry, 2010, 49(2) : 304-311.
  • 5Ingwall JS. Energy metabolism in heart failure and remodel-ling. Cardiovasc Res, 2009, 81(3) : 412-419.
  • 6Palacios OM,Carmona JJ,MchanS,et al. Diet and exercise sig-nals regulate SIRT3 and activate AMPK and PGC-1 alpha in skel-etal muscle. Aging (Albany NY) , 2009, 1(9) : 771-783.
  • 7Tao R, Coleman MC,Pennington JD, et al. Sirt3-mediateddeacetylation of evolutionarily conserved lysine 122 regulatesMnSOD activity in response to stress. Mol Cell, 2010,40?6):893-904.
  • 8Qiu X,Brown K,Hirschey MD,et al. Calorie restriction re-duces oxidative stress by SIRT3-mediated SOD2 activation.Cell Metab,2010,12(6): 662-667.
  • 9Chen Y, Zhang J, Lin Y, et al. Tumour suppressor SIRT3deacetylates and activates manganese superoxide dismutase toscavenge ROS. EMBO Rep, 2011,12(6): 534-541.
  • 10Li S,Banck M,Mujtaba S,et al. p53-induced growth arrestis regulated by the mitochondrial SirT3 deacetylase. PLoSOne, 2010, 5(5): el0486.

同被引文献40

  • 1Marie-Louise Ward,David J Crossman.Mechanisms underlying the impaired contractility of diabetic cardiomyopathy[J].World Journal of Cardiology,2014,6(7):577-584. 被引量：13
  • 2Eirini Pantazi,Mohamed Amine Zaouali,Mohamed Bejaoui,Emma Folch-Puy,Hassen Ben Abdennebi,Joan Roselló-Catafau.Role of sirtuins in ischemia-reperfusion injury[J].World Journal of Gastroenterology,2013,19(43):7594-7602. 被引量：8
  • 3董晓华,张丹参,武海霞.衰老动物模型的研究进展及评价[J].河北北方学院学报（医学版）,2004,21(6):41-43. 被引量：26
  • 4Bellizzi D, Rose G, Cavalcante P, et al. A novel VNTR enhan cer within the SIRT3 gene, a human homologue of SIR2, is as sociated with survival at oldest ages[J]. Genomies, 2005, 85 (2) 258-263.
  • 5Brachmann C B, Sherman J M, Devine S E, et al. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, ceil cycle progression, and chromosome stability [J]. Genes & Development, 1995, 9(23): 2888-2902.
  • 6Chen L, Wang F, Wang X, et al. Robust one-tube Ω-PCR strategy accelerates precise sequence modification of plasmids for functional genomics [J]. Plant and Cell Physiology, 2013, 54(4) : 634-642.
  • 7Frye R A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins[J]. Biochemical and Biophysical Research Communications, 2000, 273(2): 793-798.
  • 8Hallows W C, Lee S, Denu J M. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases[J]. Proceedings of the National Academy of Sciences, 2006, 103(27):10230-10235.
  • 9Howitz K T, Bitterman K J, Cohen H Y, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiaelifespan[J]. Nature, 2003, 425(6954):191-196.
  • 10Nakagawa T, Guarente L. Sirtuins at a glance[J]. Journal of Cell Science, 2011, 124(6): 833-838.

引证文献4

二级引证文献6

临床麻醉学杂志
2012年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部