慢性酒精中毒所致精神障碍男性患者性激素水平分析

A RETROSPECTIVE STUDY OF GONADAL HORMONE LEVELS IN THE MALE CHRONIC ALCOHOL-INDUCED MENTAL DISORDERS

目的:调查男性慢性酒精中毒所致精神障碍患者的性激素水平并分析其与精神症状之间的关系。方法:回顾性分析2004年1月-2012年2月在广州市中山大学附属第三医院住院的诊断为慢性酒精中毒所致精神障碍的男性患者共85例,分析其性激素水平并与患者精神症状进行相关分析。结果:与正常对照组相比,慢性酒精中毒所致精神障碍组患者的睾酮水平明显降低(19.78±s 12.68 vs 25.97±s 18.76),雌激素水平明显升高(111.62±s65.91 vs 92.94±s 54.13),两组比较有统计学差异(P<0.05),其余性激素指标则未见有统计学差异(P>0.05)。睾酮和雌激素水平与简明精神病评定量表中忧郁焦虑因子之间有相关性,且雌激素与忧郁焦虑因子分呈负相关(P<0.05)。结论:在慢性酒精中毒所致精神障碍的男性患者睾酮水平下降,雌激素水平升高,而雌激素水平升高可能会对患者情绪障碍起保护作用。

O bjectjve：To investigate the change of gonadal hormones level in the male chronic alcohol -induced mental disorders and to analyze the relationship between psychiatric symptoms and the gonadal hormones. Methods ： A total of male 85 patients, who met diagnostic criteria of CCMD - 3 for the chronic alcohol - induced mental disorder were hospitalized in department of psychiatry from January 2004 to February 2012. The gonadal hormone level of 85 patients and 85 normal peoples were detected and were analyzed the relationship with the psychiatric symptoms. Results： There were significant differences in testosterone （19.78± s 12. 68 vs 25.97 ± s 18.76, P 〈 0.05 ）and estrogens level （111.62± s 65.91 vs 92.94 ± s 54. 13 ,P 〈 0. 05 ）between the chronic alcohol -induced mental disorders group and normal peoples group. However, there were no statistically significant differences （ P 〉 0.05 ） in other indexs of gonadal hormones level. Correlation was found between testosterone and estrogen levels with the depression anxiety factor in Brief Psychiatric Rating Scale. The level of estrogen and depression factor scores were negatively correlated （P 〈 0.05 ）. Conclusion：The testosterone level was reduced and the estrogens was increased in the chronic alcohol -induced mental disorders. However, the increase of estrogen might play a protective role to mood disorder in these patients.