具有改善睡眠功能的五味子葡萄酒的研制

Preparation of Schisandra chinensis wine and effect on sleep improvement

以五味子为主要原料,配以人参、葡萄酒,经提取、过滤、调配、过滤、灌装制成五味子葡萄酒。依据国标检测其主要技术指标,并通过直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验、巴比妥钠睡眠潜伏期实验,来观察五味子葡萄酒改善睡眠功能的效果。结果表明:经口给小鼠灌胃30d后,各剂量组小鼠体重与对照组比较,无显著性差异。样品对受试动物无直接睡眠作用。50.0mL/kg·bw剂量能延长阈剂量戊巴比妥钠诱导的小鼠睡眠时间、缩短巴比妥钠睡眠潜伏期,与空白和酒基对照组比较差异有显著性。对阀下剂量戊巴比妥钠诱导的小鼠睡眠发生率无明显影响。结论:五味子葡萄酒具有改善睡眠作用。

The Schisandra chinensis wine＇s main materials were Schisandra chinensis, ginseng and wine, which was prepared by extracting, filtering, blending, filtering, and filling. The main qualifications were detected according to national standard, and its effect on improving sleep was carried out by the experiments of direct sleep test, Sodium Pentobarbital induced prolonging sleeping time test, the sleep- producing test of Sodium Pentobarbital sub-threshold dosage and incubation period test of Sodium Pentobarbital. The results showed that： After 30 days of administrated orally of the wine to Kunming mice, no significant difference （P〉0.05） of body weight was found between each dose group with the control group. And the direct sleeping effect of the test material was not observed. There was significant difference （P〈0.05） between 50.0 mL/kg, bw dosage of the sample with the blank and wine-based control group, respectively, which could significantly extend the sleeping time of tested mice induced by Sodium Pentobarbital, significantly shorten incubation period induced by Sodium Pentobarbital. However, no significant effect was observed to the sleeping-induced sleep-producing test of Sodium Pentobarbital sub-threshold dosage. Conclusion： Schisandra chinensis wine could improve sleep.