阿尔茨海默病68例药物治疗效果及发病机制探讨

目的观察乙酰胆碱酯酶(AChE)抑制剂石杉碱甲治疗阿尔茨海默病(AD)的疗效,并结合相关文献探讨AD的发病机制。方法对68例AD患者给予石杉碱甲治疗,共治疗48周。采用简易智力状态(MMSE)、韦氏成人记忆表(WMS)和生活功能量表(ADL)对治疗前后结果进行评分。并根据MMSE分值的改善评定疗效。结果本组68例AD患者显效10例,有效41例,无效17例,总有效率为75.0%。治疗前后MMSE、ADL、WMS评分差异有统计学意义(P<0.05)。治疗过程中4例患者出现轻微不良反应。结论石杉碱甲能有效治疗AD,老年患者顺应性好,不良反应少而轻微,值得临床应用。

Objective To observe the AChE inhibitor huperzine A treatment of Alzheimer disease （AD） efficacy, and related literature combined with the pathogenesis of AD. Methods 68 patients with AD were treated with huperzine A treatment, a total of 48 weeks. To mini-mental state （MMSE）, Wechsler Adult Memory Table （WMS）, living function （ADL）, the results of the score before and after treatment. According to the improvement of MMSE scores evaluated. Results 68 cases of AD patients were 10, effective in 41 cases, 17 cases ineffective, the total effective rate was 75.0%. Before and after treatment MMSE, ADL, WMS score difference with sex （P 〈0.05）. The course of treatment only 4 patients had mild adverse reactions. Conclusion Huperzine A is effective in treating AD, and few and mild adverse reactions in elderly patients with good compliance, it is clinical.