摘要
目的研究中国南方汉族人群中白细胞介素-16(IL-16)基因-295 T>C多态性与肾透明细胞癌(CCRCC)易感性的相关性。方法采用以医院为基础的病例对照研究模式,通过面访填写调查表并采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测年龄和性别匹配的中国南方汉族300例患者和300例正常人群的IL-16 gene-295 T>C基因型。并采用分层分析进一步探讨与罹患CCRCC相关的可能因素。结果与TT型携带者相比,CT型(OR=0.7 8,9 5%CI=0.5 5～1.09)或CC型(0.37,0.19～0.73)携带者发生CCRCC的危险性明显降低。分层分析显示年龄、体重指数及饮酒与CCRCC危险性之间无明显关联,携带CT或CC型从不吸烟的女性患者发生CCRCC的危险性明显降低(从不吸烟:0.61,0.41～0.91;女性:0.52,0.30～0.91)。结论 IL-16 gene-295 T>C多态性可能与我国南方地区汉族人群CCRCC易感性有关,CC型或CT型携带者发生CCRCC的危险性要明显低于TT型携带者。
Objective To investigate the correlation between the-295 T〉 C polymorphism in the IL-16 gene and renal cell carcinoma （RCC） risk in a southern Chinese population. Methods We obtained data from demographic factors by a personal interview. The polymorphism was ana- lyzed by polymerase chain reaction-restriction fragment length polymorphisrn （PCR-RFLP） by using genomic DNA isolated from 300 RCC patients and 300 age and sex matched controls. Stratification analysis by age, sex, smoking, drinking and BMI status was performed. Results Compared with the-295 TT genotype, individuals carrying CT genotype （OR = 0.78, 95 % CI = 0.55-1.09） or CC genotype（0.37, 0.19-0.73）had an decreasing risk of RCC. Stratified analysis found that the in- creasing risk was more pronounced among nonsmokers （0.61, 0.41-0.91 ）and female patients （0. 52, 0. 30-0. 91） . Conclusion Our data suggest that IL-16 gene-295 T〉C polymorphism may con- tribute to the etiology of renal cell carcinoma in a southern Chinese population.
出处
《实用临床医药杂志》
CAS
2012年第17期18-21,共4页
Journal of Clinical Medicine in Practice
