超敏C反应蛋白和冠状动脉造影术确定的冠心病冠脉病变严重程度相关性的直线回归分析

Correlation between high sensitive C-reactive protein with presence and extent of angiographically verified coronary artery disease by linear regression analysis

目的探讨血浆超敏C反应蛋白(hs-CRP)水平与冠心病发病和通过冠脉造影确定的病变的严重程度的关系。方法选择江苏省人民医院住院行冠状动脉造影术的707例患者,采用Gensini评分计算冠脉造影积分,入院后分别测定患者的血清hs-CRP水平。采用SPSS15.0统计软件进行直线回归分析。结果直线回归分析结果CRP的回归系数B值为0.104,P<0.001。结论血浆hs-CRP水平与冠心病冠脉病变的严重程度高度相关。hs-CRP和动脉粥样硬化的严重程度密切相关。

Objective To explore the correlation between plasma high sensitive C-reactive protein （hs-CRP） levels and occurrence and extent of angiographically verified coronary artery dis- ease. Method A total of 707 patients who were admitted to Jiangsu Provincial People＇s Hospital and have accomplished coronary angiography were included in the study. Their coronary angiogra- phy scores were calculated by C, ensini score system. Plasma hs-CRP levels and other clinic indexes were detected. SPSS15.0 was adopted to conduct linear regression analysis. Result By linear re- gression, we obtained B value of hs-CRP （B = 0. 104, P 〈 0. 001 ）. Conclusion There was strong correlation among plasma hs-CRP levels and occurrence and extent of coronary artery disease. Hs- CRP can not only indicate antherosclerosis, but also significantly associate with extent of an- therosclerosis.