适用于腔内隔绝移植物及血流动力学研究的犬肾周型腹主动脉瘤模型的建立

A canine juxtarenal abdominal aortic aneurysm model applying to endovascular stent-graft′s and hemodynamic study

目的建立一种适用于研究腔内隔绝移植物及血流动力学的犬肾周型腹主动脉瘤模型。方法通过在犬近肾腹主动脉段移植经0.6%戊二醛浸泡30 min去抗原处理后的牛颈外静脉,制作15例犬肾周型腹主动脉瘤模型。将此动脉瘤模型与患者的肾周型腹主动脉瘤进行形态学的对比,并且检测血流动力学参数并与15例腹主动脉瘤患者对比。结果 15只动物手术过程顺利,术中死亡0只,术后1天腹腔出血死亡1只,术后2天急性肾衰死亡3只。动物模型与肾周型腹主动脉瘤患者动脉瘤形态相似。直径、壁厚的比例相似。瘤体内收缩压、舒张压、平均动脉压均高于肾上腹主动脉、髂总动脉和动脉瘤入、出口。动脉壁弹性相似。动脉瘤中都出现了涡流或湍流。结论此模型是适合肾周型腹主动脉瘤腔内隔绝移植物及血流动力学研究的有较大实用价值的动物模型。

Objective To construct an animal juxtarenal abdominal aortic aneurysm model applying to endovascular stent-graft＇s and hemodynamic study. Methods The bovine jugular vein segments which had been treated with 0.6% glutaral were removed to fifteen hybrid canines at juxtare- nal abdominal aortic to construct aneurysms. The aneurysm models＇ hemodynamic data were selected and were contrasted with fifteen patients＇ juxtarenal abdominal aortic ancurysms. Results The opera- tions of all fifteen canines were successful. No canine died in the operation but 1 canine died 1 day af- ter operation because of abdominal bleeding and three died in two days because of acute renal failure. The models were similar to the patients in such area as the configuration of aneurysm, the proportion of aneurysm＇s diameter to wall＇s thickness, the elasticity of aneurysm＇s wall and the blood flow in aneu- rysm. Like the patients, the systolic, diastolic and mean pressures in the aneurysm of the model were higher than the pressures in the suprarenal aorta, the common iliac artery, the entrance of aneurysm and the exit of aneurysm. Conclusion This model can be applied in endovascular stent-graft＇s and hemodynamie study of juxtarenal abdominal aortic aneurysm.