抗菌药物临床应用专项整治前后妇产科围手术期预防用药对比分析

Intervention and Effect of Perioperative Antimicrobial Application in Department of Gynecology and Obstetrics

目的调查西安某区医院加强妇产科围手术期预防性应用抗菌药物管理的成效。方法对该院2011年6～7月和2012年6～7月产科剖宫产手术患者和妇科Ⅱ类切口手术患者围手术期抗菌药物的用药种类、给药时机、用药时限等进行回顾性分析。结果整治后,医院产科、妇科第一代头孢菌素的使用率比整治前明显提高(P<0.05);产科、妇科在术前0.5～2 h应用抗菌药物比例分别由30.0%、0提高到90.0%、50.0%(P<0.05);用药时限<48 h的比例分别由6.7%、0提高到83.3%、45.0%(P<0.05);平均用药时间分别由5.9 d、6.0 d下降到1.7 d、2.3 d(P<0.05)。结论该院妇产科围手术期预防用抗菌药物渐趋合理,但仍需进一步提高合理用药水平。

Objective To investigate the effect of intervention of prophylactic use of antimicrobials in patients during perioperative period.Methods The perioperative utilization of antibiotics for patients undergoing gynecological operation and uterine-incision delivery during June-July in 2011 and 2012 was analyzed retrospectively in respect of the type of antibiotics,the time selection of administration,the period of drug use of antibiotics.Results After special campaigns of antibiotics,the utilization ratio of first generation cephalosporin in department of obstetrics and gynecology increased（P0.05）,the proportion of phylactic application of antibiotics 0.5~2 h before operation increased from 30.0%,0 to 90.0%,50.0% respectively（P0.05）,the proportion of antibiotics after operation within 48h increased from 6.7%,0 to 83.3%,45.0% respectively（P0.05）,the average time of antibiotics use was shortened from 5.9d,6.0d to 1.7d,2.3d respectively（P0.05）.Conclusion Prophylactic use of antibiotics in perioperative patients tends to be rational.Reinforcing management of antibiotics can improve the rationality of prophylactic use.